穿琥宁注射剂不良反应病案的数据挖掘研究  

Datamining Study of Adverse Reaction of Chuanhuning Injection

作　　者：吴嘉瑞[1] 张冰[1] 

机构地区：[1]北京中医药大学,北京100102

出　　处：《药物流行病学杂志》2008年第3期156-159,共4页Chinese Journal of Pharmacoepidemiology

基　　金：国家科技支撑计划课题"中药上市后安全性监测与再评价标准规范研究"(2006BAI21B11)

摘　　要：目的:探讨穿琥宁注射剂不良反应的流行病学特点。方法:通过检索1978～2007年医药学期刊,收集穿琥宁注射剂不良反应详细病案165例;在构建数据库的基础上,应用统计学和数据挖掘方法对病案信息进行分析。结果:注射液剂型病案组中血小板减少构成比极显著高于粉针剂病案组(P<0.001);粉针剂剂型病案组中过敏性休克构成比显著高于注射液病案组(P<0.05)。10～29岁年龄段病案组中过敏性休克构成比极显著高于其他年龄段的集合(P<0.001);而血小板减少的构成比极显著低于其他年龄段的集合(P<0.001)。结论:穿琥宁注射荆不良反应类型与患者年龄、药物剂型等因素存在相关性。Objective： To investigate the epidemiological characteristics of adverse reaction caused by chuanhuning injection. Method： Domestic medical periodicals between the years of 1978 and 2006 were searched and 165 ADR cases were analyzed with the statistic and data mining method. Result： The difference of the proportion of thrombocytopenia and anaphylactic shock between different dosage forms was significant （ P 〈 0.001, P 〈 0.05 ） ; the difference of the proportion of thrombocytopenia and anaphylactic shock between different ages was very significant （ P 〈 0.001 ） Conclusion： The types of ADR caused by chuanhuning injection may be connected with patients＇age and dosage forms.

关 键 词：穿琥宁注射剂 药物不良反应 数据库 数据挖掘 

分 类 号：R181.35[医药卫生—流行病学]