南沙参多糖对小鼠CCl_4急性肝损伤的保护作用  

Protective Effects of Radix Adenophorae Potanini Korsh Polysaccharides on Hepatic injuries Induced by carbon tetrachloride in Mice

作　　者：梁莉[1] 李志诚[2] 王婷[1] 乔华[1] 李丹[1] 

机构地区：[1]兰州大学第一医院药剂科,兰州730000 [2]兰州大学医学院

出　　处：《中国药师》2008年第6期617-619,共3页China Pharmacist

基　　金：甘肃省科技攻关项目(2Gs042-A43-014-27)

摘　　要：目的:探讨南沙参多糖(RAPs)对肝损伤的保护作用。方法:采用四氯化碳(CCl_4)诱导小鼠急性肝损伤模型,测定血清丙氨酸氨基转移酶(ALT)、天冬氨酸氨基转移酶(AST)活性、肝匀浆中超氧化物歧化酶(SOD)活性及丙二醛(MDA)含量,观察肝组织病理学改变。结果:RAPS各剂量组(2000,1000,500 mg·kg^(-1))不仅能显著降低肝损伤小鼠血清AST、ALT活性,而且能够降低肝损伤小鼠肝组织MDA含量,并能提高SOD活性;病理形态学观察显示,RAPS能够明显减轻肝细胞肿胀、减少中性粒细胞浸润,其对急性肝损伤具有治疗作用。结论:RAPS对CCl_4诱导的急性肝损伤具有显著的保护作用,该保护作用可能与其抗氧化作用有关。Objective： To investigate the effects of Radix Adenophorae Potanini Korsh Polysaccharides （RAPS） on Hepatic injuries Induced by carbon tetrachloride（ CCl4 ）. Method： The liver damage model of mice was induced by CCl4. The levels of ALT, AST, SOD, MDA were determined respectively, the histopathology were observed at the same time. Result： RAPS could significantly decrease ALT, AST, MDA and elevate SOD. The histopathology indicated that RAPS could reduce hepatocytes tumidness, lessen soakage, effects of RAPS on the acute liver injuries were showed. Conclusion： RAPS showed protective effects against liver injury induced by CCl4 via its strong antioxidation.

关 键 词：南沙参多糖 肝损伤 四氯化碳 保护作用 抗氧化作用 小鼠 

分 类 号：R285.5[医药卫生—中药学]