肝泰胶囊保护对乙酰氨基酚所致急性肝损伤实验研究  

Protective Effect of Gantai Capsule on Acute Liver Injury Induced by Acetaminophen in Mice

作　　者：吴洋东[1] 虞涤霞 刘红艳[1] 高潇[1] 程勇卫[1] 段瑞娴[1] 郭燕[1] 唐望先[1] 

机构地区：[1]华中科技大学同济医学院附属同济医院肝病研究所,武汉430030 [2]武汉市第七医院

出　　处：《中国药师》2008年第6期628-630,共3页China Pharmacist

摘　　要：目的:探讨肝泰胶囊对对乙酰氨基酚(acetaminophen,AAP)所致小鼠急性化学性肝损伤的保护作用。方法:随机将小鼠分为4组,每组10只。分别给予肝泰胶囊,联苯双酯(药物对照组),0.9%氯化钠溶液(空白对照组和模型组)干预10d后,采用AAP腹腔注射,造成急性实验性肝损伤。测定各组肝损伤后的血清谷氨酸转氨酶(ALT)、天冬氨酸转氨酶(AST);肝组织中丙二醛(MDA)、谷胱甘肽(GSH)、过氧化物歧化酶(SOD);HE伊红染色观察病理改变,电镜下观察细胞器的变化。结果:肝泰胶囊能明显降低AAP所致急性肝损伤小鼠的ALT、AST活性,同时提高肝组织中GSH、SOD水平,并能明显改善肝脏组织病理。结论:肝泰胶囊对小鼠急性化学性肝损伤具一定的保护作用。Objective： To investigate the protective effect of Gantai capsule on acute liver injury induced by acetaminophen in mice. Method： Forty mice were randomly divided into four groups：Gantai capsule, bifendate,0.9 % natrii chloride and control group. Gantai capsule,bifendate and 0.9% natrii chloride were treated respectively. After 10 days , acute liver injury were induced by injecting acetaminophen into abdomen. The concentration of ALT, AST, GSH in serum and SOD, MDA in liver tissue were measured. The electron microscope was used to observe the histopathological change. Result： Gantai capsule can reduce the activity of ALT and AST in acute liver injury induced by acetaminophen, but increase the concentration of GSH and SOD in liver tissue, ultimately the pathology of liver tissue was improved. Conclusion ： Gantai capsule can protect liver from acute chemical injury in mice.

关 键 词：肝泰胶囊 对乙酰氨基酚 肝损伤 小鼠 

分 类 号：R965.1[医药卫生—药理学]