双菌多糖的抗肿瘤活性研究  

Study on Anti-tumor Activity from Fungi Polysaccharide

作　　者：张青[1] 于航[2] 陈潇滢[2] 马德章[2] 徐任[2] 于源华[2] 

机构地区：[1]长春教育学院,长春130061 [2]长春理工大学生命科学技术学院,长春130022

出　　处：《长春理工大学学报（自然科学版）》2008年第2期77-80,共4页Journal of Changchun University of Science and Technology(Natural Science Edition)

基　　金：吉林省科技厅资助项目(200504025)

摘　　要：以蒙古口蘑多糖(MOP)和紫蘑菇多糖(COP)为实验材料,分别对两种多糖和混合多糖(MCP)进行了体外和体内抗肿瘤实验,用MTT比色法测定了MOP、COP、MCP对肝癌细胞(HepG2)和人宫颈癌细胞(Hela)的抑制作用,并利用统计学方法进行分析,结果表明:三者对HepG2和Hela两种癌细胞均有一定的抑制作用,但MCP的抑制效果最好,对HepG2抑制率为72.33%,对Hela的抑制率为80.68%。MCP对S180在KM小鼠体内的增殖有明显的抑制效果,最大抑制率达到58.74%,并呈现出良好的量效关系。获得的试验结果为开发真菌双糖抗肿瘤药物提供研究基础。In this paper, Mongolia Tricholoma polysaccharide （MOP） and purple mushroom polysaccharides （COP） were as the experimental materials, a single polysaccharide components separately and mixed polysaccharide components （MCP） were used in vitro and in yivo anti-tumor experiments, with MTT assay determination of the MOP, COP, MCP of liver cancer cells （HepG2） and human cervical cancer cells （Hela） inhibition, and to make use of statistical methods for analysis. The results show that MCP inhibited effect is the best, and the inhibition rate of MCP about HepG2 is 72.33 percent, the Hela is 80,68 percent. MCP affected on S180 in KM mice significantly also, the greatest inhibition rate reached to 58.74 percent, and has shown a good dose-effect relationship. The results provide a research foundation for the development of dual-fungal sugar anticancer drug.

关 键 词：蒙古口蘑多糖 紫蘑菇多糖 抗肿瘤试验 小鼠模型 

分 类 号：O61[理学—无机化学]