Schiff-base Amino Alcohol-zinc Complex for Enantioselective Addition of Phenylacetylene to Aromatic Ketones  

作　　者：CHEN Chao HONG Liang WANG Quan ZHANG Bang-zhi WANG Rui 

机构地区：[1]State Key Laboratory for Oxo Synthesis and Selective Oxidation, Lanzhou Institute of Chemical Physics, Chinese Academy of Sciences, Lanzhou 730000, P, R. China [2]State Key Laboratory of Applied Organic Chemistry, Institute of Biochemistry and Molecular Biology, Lanzhou University, Lanzhou 730000, P. R. China

出　　处：《Chemical Research in Chinese Universities》2008年第3期306-311,共6页高等学校化学研究（英文版）

基　　金：the National Natural Science Foundation of China(Nos.20472026 and 20525206);Chang Jiang Scholar Program of the Ministry of Education, China.

摘　　要：A complete study of the asymmetric addition of phenylacetylene to ketones catalyzed by Schiff-base amino alcohol-Zn complex is reported in this article. The Schiff-base amino alcohols were easily prepared from amino acids in three steps. When the amount of ligand was 1%（molar fraction）, an e.e. value up to 94% was obtained. A series of practical chiral ligands were applied in the enantioselective addition of phenylacetylene to ketones without adding another stronger Lewis acid except zinc.A complete study of the asymmetric addition of phenylacetylene to ketones catalyzed by Schiff-base amino alcohol-Zn complex is reported in this article. The Schiff-base amino alcohols were easily prepared from amino acids in three steps. When the amount of ligand was 1%（molar fraction）, an e.e. value up to 94% was obtained. A series of practical chiral ligands were applied in the enantioselective addition of phenylacetylene to ketones without adding another stronger Lewis acid except zinc.

关 键 词：Chiral tertiary alcohol Lewis acid KETONE Schiff-base amino alcohol Sulfonamide alcohol Diol ligand 

分 类 号：O614.241[理学—无机化学]