钙磷胶体复合剂的安全性及药效检测  

Investigation of the Safety and Efficiency of the Calcium and Phosphorus Gel

作　　者：郭玺[1] 马永华[2] 赵宝玉[1] 霍星华[1] 万学攀[1] 

机构地区：[1]西北农林科技大学动物医学院,陕西杨凌712100 [2]汉中职业技术学院,陕西汉中723001

出　　处：《西北农业学报》2008年第3期54-57,共4页Acta Agriculturae Boreali-occidentalis Sinica

摘　　要：以氯化钙为主要原料,添加磷酸钙和羟乙基纤维素,制备了钙磷胶体复合剂,经检测含钙量为115±5mg/mL、含磷量为16.4±2 mg/mL。试验小鼠n=20以0.8 mL/20 g（体重）的最大剂量一日灌服2次,7 d后观察无中毒表现,剖检后组织器管无肉眼可见异常。试验组小鼠n=20以0.4 mL/20 g（体重）的剂量一日2次连续灌服7 d后,无中毒及死亡现象,小鼠平均体重由20.24±1.211 g增加到23.35±1.130 g,体重增加情况与对照组小鼠无差异。以100 mL/只灌服奶山羊（n=5）后,血钙、血磷浓度在2-3 h达到峰值（P〈0.05）,而且可维持6 h左右。Calcium chloride with calcium phosphate and hydroxyethyl cellulose was compounded to form calcium and phosphorus gel.The Ca and P contents were 115±5 mg/mL and 16.4±2 mg/mL respectively.Mice（n=20） were administered with calcium and phosphorus gel with 0.8 mL/20 g body weight twice on the first day.After 7 days,it didn＇t induce toxicosis and there were no obviously pathological changes in the important tissue and organ.When the mice in the experimental group（n=20） were administered with calcium and phosphorus gel for 7 days with the dose of 0.4 mL/20 g body weight twice daily,it did not induce toxicosis or death.The average weight of the mice increased from 20.24±1.211 g to 23.35±1.130 g.The increased trend was as the same as the control group.The milk goats（n=5） were administered with calcium and phosphorus gel with 100 mL each.The serum Ca and P concentrations were increased and reached the peak concentration after 2-3 h（P〈0.05）.And the high serum Ca and P concentrations were maintained about 6h.

关 键 词：胶体 氯化钙 磷酸钙 小鼠 奶山羊 

分 类 号：S859.79[农业科学—临床兽医学]