含稳定自由基铂配合物的合成及抗肿瘤活性研究  

Synthesis and Anti-tumor Activity of Platinum Complexes with Stable Free Radicals

作　　者：何键 陈丽萍 普绍平 李永年 

机构地区：[1]昆明贵研药业有限公司,云南昆明650106 [2]昆明地质学校,云南昆明650221

出　　处：《云南化工》2008年第3期12-14,25,共4页Yunnan Chemical Technology

基　　金：云南省人才培养基金课题(9815017)

摘　　要：将稳定氮氧自由基引入抗癌药物顺铂中,合成了二种新的稳定氮氧自由基铂配合物,通过红外光谱、质谱、元素分析确定了其结构,初步结果显示二种稳定氮氧自由基铂配合物有抗癌活性,毒性比母体化合物(顺铂)低。Two new platinum complexes with stable nitrogen - oxygen free radicals were synthesized, and their structure was characterized by IR, MS and element analysis, Preliminary result showed that two stable nitrogen - oxygen free radicals platinum complexes had anti - tumor activity and their toxicity was lower than that of cisplatin.

关 键 词：稳定氮氧自由基 铂配合物 抗癌 活性 

分 类 号：TQ463.26[化学工程—制药化工] R979.1[医药卫生—药品]