草苁蓉多糖的毒性实验研究  

Toxicity of polysaccharides of Boschniakia rossica

作　　者：费瑞[1] 迟立超[2] 杜建石[3] 付军权[2] 何源[2] 邢沈阳[4] 

机构地区：[1]东北师范大学遗传与细胞研究所,吉林长春130024 [2]吉林大学白求恩医学院,吉林长春130021 [3]吉林大学中日联谊医院,吉林长春130033 [4]吉林大学畜牧兽医学院,吉林长春130062

出　　处：《东北师大学报（自然科学版）》2008年第2期98-100,共3页Journal of Northeast Normal University(Natural Science Edition)

基　　金：吉林省科技发展计划重点项目(20050413)

摘　　要：按照我国《食品安全性毒理学评价程序和方法》的要求,采用急性毒性实验(LD50)、最大耐受量测定、小鼠骨髓嗜多染红细胞微核实验及小鼠精子畸变实验,研究了草苁蓉多糖急性毒性及遗传毒性作用.结果表明,草苁蓉多糖LD50值大于24g/kg,最大耐受量为30g/kg;小鼠骨髓嗜多染红细胞微核数量、小鼠精子畸变数量与空白对照组比较无明显差异.草苁蓉多糖属一级无毒物,未见有致突变作用.According to the China standard Procedures and Methods for Toxicological Assessmeat：on Food Safety（GB15193-2003）, the acute and inherent toxicity of Boschniakia rossica （PBR） was studied by the test of acute toxicity, maximum tolerated dose, micronucleus of bone marrow in mice and sperm abnormality in mice. The results showed that LD50 of PBR exceeded 24 g/kg, the maximum tolerated dose was 30 g/kg, and the micronucleus and the sperm abnormality rate of mice were not significantly different from blank control group. Therefor, PBR is first class non-toxicity, and without mutagenic action. PBR can be used safely in clinic for future.

关 键 词：草苁蓉多糖 急毒 致突变作用 

分 类 号：R282.71[医药卫生—中药学]