乳酸酯直接合成丙交酯的研究  

Study on direct synthesis of lactide from lactate ester

作　　者：赵文军[1] 汪群慧[1] 滕云[1] 

机构地区：[1]哈尔滨工业大学市政环境工程学院

出　　处：《哈尔滨商业大学学报（自然科学版）》2008年第3期296-299,319,共5页Journal of Harbin University of Commerce：Natural Sciences Edition

基　　金："十一五"科技支撑计划项目(2006BAJ04A06);国家"863"高技术研究发展计划资助项目(2008AA06Z34)

摘　　要：研究以中性乳酸酯为原料,以辛酸亚锡为催化剂,通过正交设计实验确定了生成丙交酯的最佳条件.在优化得出的预聚温度160℃,预聚时间7 h,催化剂用量为1.0%的条件下,丙交酯产率为61.6%;对该产物进行了熔点测定、红外光谱和核磁共振分析,证明与丙交酯的结构相符合.以中性乳酸酯为原料替代乳酸合成丙交酯的工艺,可简化从发酵起始原料到产物丙交酯的流程,避免以乳酸为原料合成丙交酯给设备造成的腐蚀,降低对反应设备材质的要求.Starting from the neutral lactate ester, lactide is synthesized with stannous octoate as catalyst. The suitable reaction conditions are found out through the orthoglnal-design experiments, that is 160 ℃, 3 h and 1.0% stannous octoate. Under this condition, the yield could reach 61.6%. The results from melting point tests, IR spectrum and ^1HNMR spectrum show that the product is lactide ; the synthesis of lactide from lactate ester can eliminate the procedure from fermentation material to the product, decrease corrosion of the reactor, lower the request of reactor material.

关 键 词：乳酸酯 合成 丙交酯 正交设计 表征 

分 类 号：O621.25[理学—有机化学]