干扰素治疗儿童手足口病临床效果分析  

Clinical study of interferon therapy for patients with hand,foot and mouth disease

作　　者：张蔓莉[1] 王箴[1] 江毅[1] 周雅燕[2] 

机构地区：[1]深圳市蛇口人民医院儿科,广东深圳518067 [2]深圳市儿童医院,广东深圳518010

出　　处：《中国儿童保健杂志》2008年第3期303-303,307,共2页Chinese Journal of Child Health Care

摘　　要：【目的】探讨干扰素-α1b治疗儿童手足口病的疗效及安全性。【方法】将256例儿童手足口病随机分为治疗组118例,给予干扰素肌注每日1次,对照组138例,给予肌注或静脉滴入利巴韦林每日1次,疗程均为3 d。【结果】治疗组的总有效率为96.62%,对照组为60.15%,两组比较差异有显著性(P<0.01)。治疗组在退热时间,手足皮疹及口腔溃疡愈合方面均优于对照组(P<0.01),治疗组未发现明显毒副作用。【结论】干扰素治疗儿童手足口病的疗效明显优于利巴韦林,值得临床上推广应用。[Objective] To evaluate the efficacy and safety of interferon α-1b on treating children with hand,foot and mouth disease. [Method] 256 children with hand foot,and mouth disease were randomly devided into two groups,therapy group with 118 cases,which were received interferon（Hapgen） by injection once daily and control group with 138 cases which were given ribavirin by intravenous or injection once daily for 3 days. [Results] The total effective rates of therapy group was 96.62%,while that of control group was 60.15%.There were significant differences between two groups（P〈0.01）.Therapy group was better than control group in temperature decreasing and cureing of skin rash and mouth ulcer.No side effect had been found in therapy group. [Conclusions] Efficacy of interferon α-1b is better than ribavirin.It is worthy of application.

关 键 词：手足口病 儿童 干扰素 

分 类 号：R722.1[医药卫生—儿科]