体外反搏对冠心病患者内皮素及组织型纤溶酶原活性的影响  

Effect of external counter pulsation on plasma endothelin and tissue plasminogen activities in patients with coronary heart disease

作　　者：王聪霞[1,2] 孙济川[1,2] 田清海[1,2] 丁抗宁[1,2] 张进虎[1,2] 

机构地区：[1]西安医科大学第二附属医院心内科 [2]陕西省人民医院

出　　处：《心功能杂志》1997年第4期215-217,共3页

摘　　要：应用体外反搏（ＥＣＰ）治疗４０例冠心病患者，按病情分为３组，急性心肌梗死５例，不稳定型心绞痛１３例，稳定型心绞痛２２例。观察ＥＣＰ前后内皮源性血管活性物质内皮素－１（ＥＴ－１）、组织型纤溶酶原激活物（ｔ－ＰＡ）及其抑制剂（ＰＡＩ－１）的变化。结果显示：反搏后ＥＴ－１含量、ＰＡＩ－１活性明显下降；ｔ－ＰＡ活性明显回升。提示ＥＣＰ治疗冠心病除血流动力学、血液流变学等因素外，还可改变内皮源性血管活性物质的活性，从而对ＥＣＰ治疗冠心病的机理提出了新的观点。40 patients with coronary heart disease treated by external counter pulsation(ECP) were divided into three groups:acute myocardial infarction(n=5),unstable angina pectoris(n=13),stable angina pectoris(n=22).Plasma endothelin 1(ET 1),tissue type plasminogen activator(t PA) and plasminogen activator inhibitor 1(PAI 1) were studied before and after ECP. The results showed that plasma ET 1 and PAI 1 decreased significantly while plasma t PA increased obviously after ECP. It is indicated that ECP treated coronary heart disease through changing levels of endothelium derived vasoactive substances besides hemodynamics and hemorrheology factors. So the new viewpoint is put forward about treating mechanisms of ECP for coronary heart disease.

关 键 词：冠心病 体外反搏 内皮素 纤溶酶原活性 组织型 

分 类 号：R541.405[医药卫生—心血管疾病]