热休克转录因子1及其突变体的研究进展  

Heat shock factor 1 and its mutant

作　　者：梁秋娟[1] 张华莉[2] 涂自智[2] 肖献忠[2] 

机构地区：[1]右江民族医学院病理生理学教研室,广西百色533000 [2]中南大学湘雅医学院病理生理学教研室,长沙410078

出　　处：《国际病理科学与临床杂志》2008年第3期205-208,共4页Journal of International Pathology and Clinical Medicine

基　　金：国家自然科学基金重点项目(30330280);国家自然科学基金(30571746)~~

摘　　要：热休克因子1(HSF1)是一种转录因子,在正常时不活化,应激时活化而具有反式激活能力。在其蛋白质结构中含有DNA结合域、三聚结构域、调节结构域、转录活化结构域等,它们在HSF1活化过程中各自发挥重要作用。通过改变HSF1的结构构建其突变体,能特异地引起或阻碍HSF1的活化。这些突变体已应用于心血管疾病、肿瘤、神经系统疾病的研究。As a transcription factor, heat shock transcription factor 1 （HSF1） is activated during stress and subsequently trans-activate its downstream factors. There are some domains in HSF1 structure such as DNA binding domain, trimerization domain, regulatory domain, and transcriptional activator domain,which play an important effect in process of HSF1 active. Changed structure and prepared HSF1 mutants could specifically active or block HSF1 activation. These mutants had been used to study in various biological questions and will help to overcome some diseases.

关 键 词：热休克因子1 显性正性突变体 显性负性突变体 

分 类 号：Q75[生物学—分子生物学]