黄芩、黄连、乌梅、金银花、败酱草对产AmpC β-内酰胺酶细菌的体外抑菌作用  

Antimicrobial activity of Scutellaria baicalensis Georgi,Coptis chinensis Franch,Prunus mume Sieb,Lonicera japonica Thunb,Patrinia scabiosaefolia Fisch on bacteria producing AmpC β-lactamases

作　　者：刘东梅[1] 毕建成[1] 郄会卿[1] 焦平[2] 闫璞玲 孟志明 

机构地区：[1]河北省中医院检验科,河北石家庄050011 [2]河北省中医院儿科,河北石家庄050011 [3]河北省兴隆县人民医院妇产科,河北兴隆067300

出　　处：《河北中医》2008年第6期654-655,共2页Hebei Journal of Traditional Chinese Medicine

基　　金：河北省科学技术研究与发展指导计划项目(第一批)(编号:072761292)

摘　　要：目的探讨黄芩、黄连、乌梅、金银花、败酱草对产AmpC β-内酰胺酶细菌的体外抑菌作用。方法采用M-H琼脂稀释法对黄芩、黄连、乌梅、金银花、败酱草进行体外抑菌活性检测。结果黄芩、黄连、乌梅、金银花、败酱草对产AmpC β-内酰胺酶细菌有不同程度的抑菌作用,其中黄芩、黄连、乌梅的抑菌效果较好,其最低抑菌浓度(MIC)90分别为15.62、31.25、31.25mg/mL。结论黄芩、黄连、乌梅可用于临床治疗由产AmpC β-内酰胺酶细菌引起的感染。Objective To investigate the antimicrobial activity of Scutellaria baicalensis Georgi, Coptis cbinensis Franch, Prunus mume Sieb, Lonicera japonica Thunb, Patrinia scabiosaefolia Fisch on bacteria producing AmpC β- lactamases. Methods Antimicrobial activity of Scutellaria baicalensis Georgi, Coptis chinensis Franch, Prunus mume Sieb, Lonicera japonica Thunb, Patrinia scabiosaefolia Fisch was detected by M - H agar dilution method. Results The results showed that they had different antimicrobial activity, the effects of Scutellaria baicalensis Georgi, Coptis chinensis Franch, Prunus mume Sieb were better, their MIC90 was 15.62,31.25,31.25 mg/mL, respectively. Conclusion Scutellaria ba- icalensis Georgi, Coptis chinensis Franch, Prunus mume Sieb can be used to treat the infection caused by bacteria producing AmpC β- lactanmses.

关 键 词：中草药 微生物敏感性试验 革兰阴性杆菌 β-内酰胺酶类 黄芩 黄连 乌梅 金银花 败酱草 

分 类 号：R282.710.5[医药卫生—中药学] R978.1[医药卫生—中医学]