维生素E对乙醇性肝损伤大鼠肝线粒体SOD和MDA的影响  

Effect of Vitamin E on SOD and MDA in Hepatocyte Mitochondria of Rats Injured by Alcohol

作　　者：金海燕[1] 裴风郁[1] 朴熙绪[1] 

机构地区：[1]延边大学医学院附属医院,延吉市133000

出　　处：《中西医结合肝病杂志》1997年第4期221-223,共3页Chinese Journal of Integrated Traditional and Western Medicine on Liver Diseases

摘　　要：目的:研究维生素E在乙醇性肝损伤肝组织亚细胞水平上的作用。方法:采用乙醇性肝损伤大鼠模型,测定乙醇灌胃及其VitE处理后肝线粒体SOD、MDA。结果:乙醇灌胃后肝线粒体SOD下降,而MDA上升;维生素E处理后SOD明显上升,MDA下降。结论:VitE可使乙醇性肝损伤大鼠肝线粒体SOD、MDA趋向正常,有抗氧化作用。Aim: At subcellular level to study the action of Vitamin E on hepatic tissue injured by alcohol. Method: Made rat's model injured by alcohol and measured the activities of SOD and Contents of MDA after giving ethanol and Vitamin E (only treatment group) by intragastric perfu-sion, respectively. Result: SOD activities reduced and MDA contents increased in hepatocyte mitochondria of experiment group, and after treatment with Vitamin E, SOD activities increased and MDA contents reduced. Conclusion: Vitamin E had antioxidation and could make SOD and MDA in hepatocyte mitochondria of rats injured by alcohol tend towards improvement.

关 键 词：维生素E 肝损伤 超氧化物歧化酶 MDA 

分 类 号：R977.25[医药卫生—药品] R575.05[医药卫生—药学]