神经介素U与摄食调控的研究  

Study of neuromedin U in regulation of food intake

作　　者：袁良杰[1] 卢霞[1] 瞿颂义[1] 

机构地区：[1]兰州大学基础医学院生理和心理研究所,甘肃省新药临床前研究重点实验室,730000

出　　处：《国际内分泌代谢杂志》2008年第4期256-258,共3页International Journal of Endocrinology and Metabolism

基　　金：国家自然科学基金资助项目（30572428）730000

摘　　要：神经介素U首次是从锗脊髓中分离得到并提纯的，在体内分布广泛，主要分布在胃肠道和中枢，其受体为G蛋白祸联受体的配体FM-3和FM-4，即神经介素U受体1和神经介素U受体2。最近研究发现,神经介素U为内源性抑食肽，具有抑制摄食、增加自主活动、促进机体代射、调节能量平衡的作用。本文主要介绍神经介素U及其受体在摄食调控方面的研究。Neuromedin U,first isolated from porcine spinal cord,is widely distributed with highest expression in the gastrointestinal tract and the central nervous system. Its receptors are the endogenous ligands for two G protein-coupled receptors, FM-3 （ neuromedin U receptor 1 ） and FM-4 （ neuromedin U receptor 2）. Reeently,neuromedin U is found to be as an endogenous anorexigenie peptide. It can inhibit food intake, increase the locomotor activity,promote the metabolism of the body and regulate energy homeostasis. This review mainly introduces the roles of neuromedin U and its two reeeptors in regulation of food intake.

关 键 词：神经介素U 神经介素U受体2 摄食 

分 类 号：R589.2[医药卫生—内分泌]