大小动脉顺应性与老年人眼底动脉硬化的关系  

Association between arterial compliance and fundus oculi arteriosclerosis in elderly people

作　　者：张红[1] 李小利[2] 高海青[1] 刘远萍[1] 王敏[1] 孙秀芳[1] 马亚兵[1] 

机构地区：[1]山东大学齐鲁医院干部保健科,山东济南250012 [2]山东大学齐鲁医院药品采购科,山东济南250012

出　　处：《中华老年医学杂志》2008年第6期416-419,共4页Chinese Journal of Geriatrics

摘　　要：目的探讨大、小动脉顺应性与眼底动脉硬化的关系及其相关危险因素。方法选取山东大学齐鲁医院老年病科就诊的老年眼底动脉硬化患者61例，在健康体检中心健康查体的老年人群中根据卫生部药物临床试验指导原则中健康人的筛选标准，并结合体格检查和年龄，筛选出健康人12例，采用CVProfilor DO-2020动脉功能测定仪检测大动脉弹性指数（C1）和小动脉弹性指数（C2），并采用佳能免散瞳数码眼底照相机进行眼底照相，分为眼底动脉I级组、Ⅱ级组、Ⅲ级组和正常组。结果老年眼底动脉硬化患者收缩压、舒张压、平均动脉压、脉压、C1和C2与健康人比较，差异均有统计学意义（P〈0.01或P〈0.05）；单因素相关分析表明，眼底动脉硬化级别与收缩压、舒张压、平均动脉压和脉压呈正相关（r=0．357、0．261、0．342、0．280，均为P〈0．05），其中与收缩压相关性最显著；眼底动脉硬化级别与C1、C2呈负相关（r=0．281、-0．308，P〈0．05、P〈0．01），眼底动脉硬化级别与C2相关性最为显著。结论老年眼底动脉硬化患者C1和C2均降低，其中C2降低更为显著，可能是老年患者心血管危险事件的早期预测因子，亦可作为老年动脉硬化患者的一个治疗指标。Objective To investigate the association between arterial compliance and fundus oculi arteriosclerosis in elderly people. Methods A total of 73 elderly subjects, including 61 elderly patients with fundus oculi arteriosclerosis and 12 healthy volunteers were recruited into the study. Capacitive arterial compliance （C1） and oscillatory arterial compliance （C2） were measured by DO-2020 Cardiovascular Profiling Instrument. Moreover, fundus photographs were measured using Canon figure fundus camera. Results There were significant differences in systolic blood pressure（SBP） , diastolic blood pressure（DBP）, mean artery pressure, pulse pressure, capacitive arterial compliance （C1）, and oscillatory arterial compliance （C2） between patients with fundus oculi arteriosclerosis and healthy volunteers （all P〈0.05）. In multiple regression analysis, the grade of fundus oculi arteriosclerosis was significantly correlated with SBP, DBP, mean artery pressure and pulse pressure （r=0.357, 0.261, 0.342, 0.280, all P〈0.05）. Moreover, there were significant correlations between the grade of fundus oculi arteriosclerosis and C1 （r=-0.281, P〈0.05）, and C2 （r=-0.308, P〈0.01）. Conclusions These findings underscore the efficacy of C1 and C2 in identifying patients with fundus oculi arteriosclerosis.

关 键 词：眼底 动脉硬化 血压 

分 类 号：R686[医药卫生—骨科学]