血液透析患者庚型肝炎病毒感染情况分析  

HEPATITIS G VIRUS IN HEMODIALYSIS PATIENTS

作　　者：陆福明[1,2] 樊淑玲[1,2] 丁峰[1,2] 袁正宏 林善锬[1,2] 

机构地区：[1]上海医科大学附属华山医院肾脏病科 [2]上海医科大学分子病毒卫生部重点实验室

出　　处：《肾脏病与透析肾移植杂志》1997年第6期536-539,共4页Chinese Journal of Nephrology,Dialysis & Transplantation

摘　　要：目的：探讨庚型肝炎病毒（ＨＧＶ）在维持性血液透析（ＨＤ）患者中的流行情况及感染相关因素。方法：应用半套式ＲＴ－ＰＣＲ方法检测１０２名ＨＤ患者血清ＨＧＶ，并分析其与透析时间、输血、肝功能损害及ＨＣＶ、ＨＢＶ感染的关系。结果：ＨＤ患者ＨＧＶ感染率达１６％，远高于正常对照人群的２．５％，（Ｐ＜０．０１）。ＨＧＶ感染相关因素分析提示：随着透析时间的延长，输血次数的增加，ＨＧＶ感染率明显增高；ＨＧＶ伴发ＨＣＶ感染的发病率明显增高，达３８％，并增加了肝功能损害的机率，（Ｐ＜０．０５）。结论：ＨＤ患者是ＨＧＶ感染的高危人群，其高发生率可能与输血有关，ＨＧＶ多与ＨＣＶ同时感染，并可能诱发肝损害。OBJECTIVE To evaluate the prevalence and clinical relevance of hepatitis G virus (HGV) infection in maintenance hemodialysis(HD) patients.METHODOLOGY 102 HD patients were included in this study. Reverse transcription polymerase chain reaction(RTPCR) was used to detect HGV RNA and HCV RNA. The prevalence and clinical manifestation were investigated, and the risk factors and coinfection with HBV or HCV were analyzed.RESULTS HGV RNA was positive in 16 percent of the patients on hemodialysis (16 in 102), while in 2.5 percent of health blood donors (1 in 40). The difference was of significance (P<0.01). Increased serum level of alamine transferase level was found in more patients positive for HGVRNA as compared to those negative for HGVRNA. Risk factors as the time on HD and the frequency of blood transfusion were determined. The prevalence of HBsAg(2 in 16) or HCV RNA positivity(6 in 16) was significantly higher in patients positive for HGVRNA than in patients negative for HGVRNA(4 in 86 for both).CONCLUSION Patients on maintenance HD are at increased risk of HGV infection. The risk factors as duration of HD treatment and frequency of blood transfusion were determined.

关 键 词：血液透析 庚型肝炎病毒 感染 

分 类 号：R512.63[医药卫生—内科学] R459.5[医药卫生—临床医学]