影响胶质母细胞瘤切除术后的预后因素分析  

Prognostic factors of patients with glioblastoma after tumor resection

作　　者：马翔宇[1] 李新钢[1] 刘佳[2] 吕亚峰[1] 王东海[1] 吴鑫[3] 刘卫东 徐淑军[1] 李刚[1] 

机构地区：[1]山东大学齐鲁医院神经外科,济南250012 [2]山东省立医院 [3]烟台毓璜顶医院神经外科 [4]聊城市脑科医院神经外科

出　　处：《中华神经外科杂志》2008年第6期464-467,共4页Chinese Journal of Neurosurgery

基　　金：国家自然科学基金资助项目（30672163）;山东省卫生系统杰出学科带头人基金资助项目（2003-17）.志谢：衷心感谢青岛大学附属烟台毓璜顶医院刘运祥、姚卫东,聊城市脑科医院李忠民、王继耀、张连群在本研究病历收集过程中给予的大力支持.

摘　　要：目的探讨影响胶质母细胞瘤切除术后的预后因素。方法对山东省三家医院1999—2004年经手术治疗且随访资料完整的205例胶质母细胞瘤进行回顾性研究，Kaplan—Meier单因素分析筛选预后相关因素，并通过Cox回归模型对筛选出的相关因素进行多因素分析。结果患者中位生存期为12.0个月，术后6、12、18、24个月的积累生存率分别为82％、52％、27％、17％。多因素分析显示年龄、肿瘤部位、术前KPS评分、手术切除程度、术后放疗、化疗是影响预后的主要因素。结论经多因素分析证实肿瘤的切除程度、术后放疗和化疗均能显著影响胶质母细胞瘤的预后，其中放疗是最具统计学意义的治疗方式。Objective To analyze the survival time of Chinese patients with GB, identify significant independent prognostic factors in patients of GB after tumor resection. Methods 205 patients operated on for GB from 1999 to 2004 were followed up. Univariate analysis of prognosis factors of survival time was performed. The significant factors found in univariate analysis were tested in multivariate analysis using the COX regression method. Results The overall cumulative survival rate was 82 at 6 months, 52 at 12 months, 27 at 18 months and 17 at 24 months. Using multivariate analysis, the following prognosis factors were found to influence survival： age, preoperative KPS score, radical surgery, tumor location, radiotherapy, chemotherapy. Conclusions Radical surgery, radiotherapy and chemotherapy are significant independent prognostic factors in patients of GB after tumor resection.

关 键 词：胶质母细胞瘤 外科手术 生存分析 

分 类 号：R686[医药卫生—骨科学]