血糖水平对^18F—FDG PET／CT图像质量的影响  

Effect of blood glucose level on ^18F-FDG PET/CT imaging

作　　者：谭海波[1] 林祥通[1] 管一晖[1] 赵军[1] 左传涛[1] 华逢春[1] 汤文英[1] 

机构地区：[1]复旦大学附属华山医院PET中心,上海200235

出　　处：《中华核医学杂志》2008年第3期209-212,共4页Chinese Journal of Nuclear Medicine

摘　　要：目的研究血糖水平对^18F-脱氧葡萄糖（FDG）PET／CT图像质量的影响。方法80例行体格检查或评价肿瘤性质的受检者，按空腹血糖水平分为9组（组间距为1mmol／L），第1组为血糖正常组，即血糖〈6．0mmol／L（10例）；第2～9组血糖水平高于正常，分别为6．0—6．9mmol／L（11例），7．0—7．9mmol／L（13例），8．0～8．9mmol／L（11例），9．0～9．9mmol／L（11例），10．0～10．9mmol／L（8例），11．0～11．9mmol／L（6例），12．0～12．9mmol／L（5例），≥13．0mmol／L（5例）。受检者做完PET／CT检查后，图像质量由2位有经验的医师独立判断。同时根据肝不同层面的标准摄取值（SUV）最大值（SUVmax）及SUV平均值（SUVavg）分别计算肝图像噪声。采用SPSS 12．0软件进行统计学处理。结果（1）9组之间图像质量评分、肝噪声差异有统计学意义（P均〈0．05）。将第2～9组图像质量评分、肝噪声分别与第1组进行比较，第2～7组与第1组差异无统计学意义（P均〉0．05）；第8，9组与第1组比较差异有统计学意义（P均〈0．05），且评分低于第1组。（2）血糖水平与图像质量评分呈负相关（r=-0．52，P〈0．05）；血糖水平与肝噪声呈正相关（SUVmax、SUVavg r值分别为0．33和0．60，P均〈0．05）；SUVavg所算噪声与血糖水平的相关性优于SUVmax。结论图像质量随血糖水平的升高而下降，血糖〈12．0mmol／L时与血糖正常者PET／CT图像质量差异无统计学意义，但当血糖水平≥12．0mmol／L时图像质量将显著下降。Objective The aim of this study was to investigate the effect of blood glucose level on the image quality of ^18 F-fluorodeoxyglucose （FDG） PET/CT imaging. Methods Eighty patients referred to the authors＇ department for routine whole-body ^18F-FDG PET/CT check up were recruited into this study. The patients were classified into 9 groups according to their blood glucose level ： normal group 〈 6.0 mmol/L（ n = 10）, 6.0-6.9 mmol/L（n=11）, 7.0-7.9 mmol/L（n=13）, 8.0-8.9 mmol/L（n=11）, 9.0-9.9 mmol/L（n=11）, 10.0-10.9mmol/L（n=8）, 11.0-11.9 mmol/L（n=6）, 12.0-12.9mmol/L（n= 5）, ≥13.0 mmol/L（n = 5）. The image quality was reviewed independently by two experienced doctors. The noise level was calculated according to the average and maximum standardized uptake value （SUVavg and SUVmax ） of liver on different slices. SPSS 12.0 was used to analyse the data. Results （ 1 ） There were significant differences among the 9 groups in image quality scores and image noises （ all P 〈 0.05 ）. Using the first group as normal reference, there were no significant differences in image quality scores and image noises from group 2 to group 7. However, groups 8 and 9 showed statistical significant differences contrasted to group 1 （ P 〈 0.05 ）. The image quality scores of groups 8 and 9 were less but the image noises were higher than that of group 1. （2）There was negative correlation between image quality scores and blood glucose level （ r = - 0.52 ,P 〈 0.05 ） . The image noise was positively correlated with blood glucose level （ r of SUVavg and SUVmax ： 0.60 and 0.33, P 〈 0.05 ） . Conclusions The higher the blood glucose level, the worse the image quality. When the blood glucose level is more than or equal to 12.0 mmol/L, the image quality will significantly degrade.

关 键 词：血糖 体层摄影术 发射型计算机 体层摄影术 X线计算机 脱氧葡萄糖 质量控制 

分 类 号：R686[医药卫生—骨科学]