商陆皂苷甲对大鼠抗Thy1系膜增生性肾炎的治疗作用  

Observation of Therapeutical Effects of Esculentoside A on Rats with MsPGN Induced by Anti-Thy1

作　　者：张亮[1] 张克非[2] 吴雄飞[3] 

机构地区：[1]浙江省舟山市人民医院肾内科,舟山316000 [2]遵义医学院附属医院肾内科,遵义563003 [3]第三军医大学附属西南医院肾科,重庆400038

出　　处：《中国中西医结合肾病杂志》2008年第6期506-508,I0003,共4页Chinese Journal of Integrated Traditional and Western Nephrology

基　　金：贵州省卫生厅科研基金资助项目(NoD-184)

摘　　要：目的:探讨商陆皂苷甲(EsA)对大鼠抗Thy1系膜增生性肾炎的治疗作用。方法:制备大鼠抗Thy1系膜增生性肾炎模型,随机分为EsA治疗组、地塞米松治疗组、未治疗组(模型组)。另设正常对照组。隔日测定24h尿蛋白定量。所有大鼠第8天处死,取肾脏组织,显微镜观察肾组织系膜增生程度,利用图像分析系统对系膜区占据肾小球面积进行分析。结果:EsA治疗组及地塞米松治疗组3、5、7天24h尿蛋白与模型组相应时间点比较均明显下降(P<0.01～0.001);EsA治疗组及地塞米松治疗组肾小球系膜细胞及基质增生程度较模型组明显减轻(P<0.05)。结论:EsA对大鼠抗Thy1系膜增生性肾炎具有降低尿蛋白、抑制肾小球系膜细胞及系膜基质的增生的作用。Objective：To observe the therapeutical effects of Esculentoside A（EsA） on rats with mesangialproliferative glomerulonephritis（MsPGN） induced by anti-Thy1 antibody.Methods：The rats with MsPGN were randomly divided into 3 groups,EsA group,DXM group and Model group;another group is normal group,and each group contained 6 rats.Urine volume and urinary protein were examined every 2 days.All of rats were killed on the 8th day.Pathologic morphology of kidney was observed with Microscope and Image Analysis system.Results：The amount of urinary protein in model group was significantly higher than those in EsA group and DXM group（P〈0.01～0.001）.Glomerular mesangium cell and matrix in model group were obviously more proliferative than those in EsA group and DXM group.Conclusion：It is suggested that EsA possesses effects of reducing the urinary protein excretion,and inhibiting the proliferation process of glomerular mesangium and matrix of MsPGN.

关 键 词：抗Thy1 系膜增生性肾炎 动物模型 商陆皂苷甲 

分 类 号：R285.5[医药卫生—中药学]