腺病毒载体在乙型肝炎生物治疗中的应用  

Application of adenoviral vector in biotherapy for hepatitis B virus infection

作　　者：韩红霞[1] 唐红[1] 

机构地区：[1]四川大学华西医院感染性疾病中心生物治疗国家重点实验室感染性疾病研究室,四川省成都市610041

出　　处：《世界华人消化杂志》2008年第15期1649-1654,共6页World Chinese Journal of Digestology

基　　金：国家重点基础研究973计划资助项目;No.2006CB504300~~

摘　　要：乙型肝炎病毒(hepatitis B virus,HBV)感染是一个严重的公共卫生问题,特别是在我国,约有1.2亿人为慢性HBV携带者.对已感染HBV者,目前治疗效果尚不理想,生物治疗为其提供了新的思路.理想的载体系统是决定生物治疗效率的重要因素.腺病毒载体由于自身的优势在乙型肝炎生物治疗研究中受到越来越多的重视.本文就腺病毒载体在乙型肝炎生物治疗研究中的应用作一综述.Hepatitis B virus （HBV） infection is a worldwide public health problem. Especially in China about 120 million are estimated to be HBV chronic carriers. For those infected with HBV, there has been no curable treatment. However, biotherapy provides a new clue for future treatment. An appropriate vector is the essential factor in determining efficiency of biotherapy. Owe to its own properties, Adenoviral vector has gained increasing interest in the biotherapy of HBV infection resently. This review focused on the progress in the biotherapy of HBV infection using adenoviral vector.

关 键 词：乙型肝炎病毒 腺病毒载体 生物治疗 基因治疗 

分 类 号：R512.62[医药卫生—内科学] R394[医药卫生—临床医学]