组蛋白赖氨酸甲基化与去甲基化  

Methylation and Demathylation of Histone Lysine

作　　者：张丽[1] 戴勇[1] 

机构地区：[1]深圳市人民医院临床医学研究中心暨南大学第二临床学院,广东省深圳市518020

出　　处：《医学分子生物学杂志》2008年第3期273-277,共5页Journal of Medical Molecular Biology

摘　　要：组蛋白赖氨酸甲基化是组蛋白尾段发生的一种重要共价修饰,在基因的表观遗传转录调控中起着关键的作用。目前,组蛋白H3的K4、K9、K27、K36、K79和H4的K20是组蛋白赖氨酸甲基化的常发位点,不同位点的甲基化及甲基化程度会引发不同的效应。随着组蛋白赖氨酸甲基转移酶和去甲基化酶的陆续发现,对组蛋白赖氨酸甲基化有了一个全新的认识,走出了一直认为组蛋白赖氨酸甲基化是一个稳定修饰的误区,与此同时,组蛋白的去甲基化也受到更为广泛的关注。The methylation of histone lysine is an important covalent modification at its tails and plays a key role in epigenetic regulation. The regular sites of histone H3 are K4, K9, K27, K36, K79 and K20 of the histone H4. The effects vary with the intensity and sites of methylation. In recent years, with more and more histone lysine methyltransferases and demethyhransferases being identified, we have better understanding of histone lysine methylation and the misconception that histone lysine methylation is a stable modification has been discarded. And now the histone demethylation is also attracting the attention of researchers.

关 键 词：组蛋白赖氨酸 甲基化 组蛋白赖氨酸甲基转移酶 组蛋白赖氨酸去甲基转移酶 

分 类 号：Q75[生物学—分子生物学]