1-萘酚的β-取代金属卟啉的合成及其抗菌活性  

Synthesis and antibacterial activity of β-substituted metal porphyrins of 1-naphthol

作　　者：章颖[1] 肖欣[1] 邓鹏星[1] 黄齐茂[1] 潘志权[1] 陈彰评[2] 

机构地区：[1]武汉工程大学化工与制药学院省部共建绿色化工过程教育部重点实验室,湖北武汉430074 [2]武汉大学化学与分子科学学院,湖北武汉430072

出　　处：《武汉工程大学学报》2008年第4期8-11,共4页Journal of Wuhan Institute of Technology

基　　金：国家自然科学基金(No.20471045)资助项目

摘　　要：为了研究新型光敏剂,利用1-萘酚和2-硝基-5,10,15,20-四苯基金属卟啉反应,合成了2-(1-羟基萘基)-5,10,15,20-四苯基金属卟啉,产率达70%以上,并对其结构进行表征.研究了2-(1-羟基萘基)-5,10,15,20-四苯基铜卟啉和镍卟啉对金黄色葡萄球菌(Staphylococcus aureus ATCC 25923)的抑菌活性,发现2-(1-羟基萘基)-5,10,15,20-四苯基镍卟啉具有一定的光敏抑菌活性.To study novel photosensitizers, 2-（1-hydroxynaphthyl）-5, 10, 15,20 tetraphenylpo - rphyrinato metal compounds have been synthesized by rbaction of 2-nitro-5, 10, 15, 20- tetraphenylporphyrinato metal comiaounds with 1-naphthol in higher than 70% yields and their structures were characterized. The bactericidal activity on Staphylococcus aureus ATCC 25923 has been tested with 2-（1-hydroxynaphthyl）-5,10,15,20-tetraphenylporphyrinato metal compounds. It is shown that the Ni（ Ⅱ ） complexes has photodynamic antibacterial activity.

关 键 词：2-(1-羟基萘基)-5 10 15 20-四苯基金属卟啉 合成 抗菌活性 光敏剂 

分 类 号：O621.3[理学—有机化学]