竹红菌甲素和溶菌酶之间的电子转移与荧光猝灭作用(英文)  

Affinity Interaction Between Lysozyme and Hyprocrellin A:Electron Transfer and Fluorescence Quench

作　　者：宋开玺[1] 周家宏[1] 吴晓红[2] 周林[1] 顾晓天[1] 魏少华[1] 冯玉英[1] 王雪松[3] 

机构地区：[1]南京师范大学分析测试中心江苏省生物功能材料重点实验室,江苏南京210097 [2]江苏经贸职业技术学院工程技术系,江苏南京210007 [3]中国科学院理化技术研究所,北京100101

出　　处：《南京师大学报（自然科学版）》2008年第2期59-64,共6页Journal of Nanjing Normal University(Natural Science Edition)

基　　金：Supported by the National Natural Science Foundation of China(20603018);the Natural Science Foundation of Jiangsu Edu-cation Department(04KJB150068)

摘　　要：在光动力疗法中,竹红菌甲素作为敏剂与溶菌酶发生了相互作用.本文对竹红菌甲素同溶菌酶作用的荧光猝灭机理进行了研究.结果表明,竹红菌甲素与溶菌酶结构中的酪氨酸和色氨酸之间的光诱导电子转移机制,在荧光猝灭过程中起了重要作用.Based on the known binding interaction between lysozyme and hypocrellin A, a photosensitizing drug used in photodynamic therapy, and the fluorescence quenching mechanism of lysozyme by hypocrellin A was studied. The results indicated that the photoindueed electron transfer between the tryptophan and tyrosine residues of lysozyme and hypocrellin A plays an important role in this fluorescence quenching process.

关 键 词：竹红菌甲素 溶菌酶 结合作用 光诱导电子转移 

分 类 号：O641[理学—物理化学]