克汀病人血Cu、Zn、Se含量及CuZn SOD、SeGSH-Px活性观察  

The Concentration of Cu、Zn、Se and the Activity of Superoxide Dismutase, Glutathione Peroxidase in the Blood of Critinism Patients

作　　者：万昌武[1] 卢步峰[1] 董仲[1] 刘家骝[1] 

机构地区：[1]贵阳医学院病理学教研室

出　　处：《贵阳医学院学报》1997年第3期213-215,共3页Journal of Guiyang Medical College

基　　金：贵州省教委资助

摘　　要：测定地方性克汀病患者、病区正常成人血液中Ｃｕ、Ｚｎ、Ｓｅ含量及红细胞ＣｕＺｎＳＯＤ、ＳｅＧＳＨ－Ｐｘ活性，发现克汀病患者及病区正常人血Ｚｎ、Ｓｅ含量低，红细胞ＣｕＺｎＳＯＤ、ＳｅＧＳＨ－Ｐｘ活性显著低于非病区成人，克汀病人ＳＯＤ活性还显著低于病区正常成人。同时测定病区粮食、饮水、土壤中相应元素含量，发现病区居民主食Ｚｎ、Ｓｅ含量低，病区人群Ｚｎ、Ｓｅ代谢紊乱可能正是由于环境中两种元素缺乏的结果。The concentration of Cu,Zn,Se and the activity of CuZn SOD,Se GSH Px of red blood cell were determined in 21 cases of critinism patients and 15 cases of nomal adults living in the same endemic region.The contents of same elements in the soil,drinking water,rice and corn from this region were also assayed.The results showed that the concentrations of Zn,Se and the activity of CuZn SOD,Se GSH Px in critinism patients and the nomal adults living in the endemic region were lower than those in the adults from a nonendemic region.The activity of CuZn SOD in the patients was much lower than that of the adults living in the same region.The contents of Cu,Zn,Se in these living materials of the endemic region were lower at differential degree than those of the non endemic region.Our results suggest that the people living in the endemic region showed the disturbances of Zn and Se metabolism,and some defects of relative enzymes,which were brought about by the shortage of these elements in their living environment.

关 键 词：克汀病 地方病 血液 微量元素 GSH-PX SOD 

分 类 号：R581.21[医药卫生—内分泌] R599.9[医药卫生—内科学]