人细小病毒B19感染与自然流产关系的研究  

Relationship between Human Parvovirus B19 Infection and Spontaneous Abortion

作　　者：王荣平[1,2] 陈星琪[1,2] 韩美玉 姜静雯 张国成[1,2] 

机构地区：[1]第四军医大学附属第一医院儿科 [2]广州军区武汉总医院心胸外科

出　　处：《中华妇产科杂志》1997年第9期541-543,共3页Chinese Journal of Obstetrics and Gynecology

摘　　要：目的：探讨人细小病毒Ｂ１９感染与自然流产之间的关系。方法：用巢式聚合酶链反应技术检测１０５例（病例组）自然流产胚胎组织标本中的Ｂ１９病毒ＤＮＡ，并取２０例胚胎组织和２０例胎肝作对照，Ｂ１９病毒阳性标本作合并ＴＯＲＣＨ感染的诊断。结果：病例组检出２６例阳性（２４．８％），对照组检出２例阳性（５．０％），（Ｐ＜０．０５）。２６例阳性标本中，５例合并巨细胞病毒（ＣＭＶ）感染，２例合并ＣＭＶ、单纯疱疹病毒感染。结论：Ｂ１９病毒感染可能是引起自然流产的重要原因。Objective: To determine whether there is a relationship between parvovirus B19 infection and spontaneous abortion. Methods: 105 embryo tissues from spontaneous abortions of unknown cause during 1994-1995 were studied using nested Polymerase Chain reaction (PCR) assay for parvovirus B19 DNA. As controls 40 fetal tissues were also examined. Among which, 20 were collected from induced abortions, and the others were stillbirths. The positive specimens underwent further study for TORCH infections. Results: 26 (24.8%) were B19 DNA positive in the case group and 2 (5.0%) in the control group. The difference was significant ( P <0.05). Among 26 positive specimens, 5 had cytomegalovirus (CMV) infection as well as 2 had both CMV and herpes simplex virus (HSV) infections. Conclusions: Parvovirus B19 infection may be an important pathogen for spontaneous abortion, and it is suggested to investigate parvovirus B19 infection among pregnant women in China.

关 键 词：细小病毒B19 自然流产 聚合酶链反应 病毒感染 

分 类 号：R714.21[医药卫生—妇产科学] R373.9[医药卫生—临床医学]