L-卡尼汀与卡维地洛对实验性心力衰竭大鼠血浆降钙素基因相关肽含量及其对心肌重构的影响  

Effect of L-carnitine and carvedilol on calcitonin gene related peptide and myocardial remodeling in rats with heart failure

作　　者：王宏岭[1] 王希柱[2] 

机构地区：[1]华北煤炭医学院附属医院 [2]华北煤炭医学院附属唐山市人民医院,河北唐山063000

出　　处：《华北煤炭医学院学报》2008年第4期437-439,共3页Journal of North China Coal Medical College

摘　　要：①目的探讨L-卡尼汀与卡维地洛对实验性心力衰竭(心衰)大鼠血浆降钙素基因相关肽(CGRP)含量及其对心肌重构的影响。②方法用盐酸阿霉素(或称盐酸多柔比星.Doxo-rubicin Hydrochloride,ADR)腹腔注射诱导大鼠心衰,随机分为4组,即心衰对照组(CHF组);卡尼汀治疗组、卡维地洛治疗组;卡尼汀联用卡维地洛治疗组(L&C组)。另设假手术正常对照组。分别测量大鼠左室收缩末期、舒张末期内径、体重和心室质量,比色法测血浆游离脂肪酸(FFA)含量,放免法测定血浆CGRP含量。③结果心衰大鼠左室舒缩功能减退,血浆CGRP水平显著降低,血浆FFA明显升高;左室收缩末期、舒张末期内径、体重和心室质量各组比较差异显著;③L-CN组、CAR组、L&C组血浆CGRP含量较CHF组有明显升高,血浆FFA明显降低,L&C组较L-CN组、CAR组有明显差异。④结论L-卡尼汀、卡维地洛及二者联用均能提高实验性心力衰竭大鼠血浆降钙素基因相关肽(CGRP)含量,降低血浆FFA含量,并且可以在一定程度上缓解心衰及左室重构。Objective To explore the effect of L- carnitine （L -CN） and Carvedilol （Car） on the calcitonin gene related peptide （CGRP） in experimental rats with congestive heart failure（CHF）. Methods SD rats with HF were made by the peritoneal injection with Doxo- rubicin Hydrochloride（ADR） and randomly divided into four groups（ each group 8 cases） ：HF control group （CHF group）,L- carnitine（ L- CN） treatment group, Carvedilol（CAR） treatment group and Carvedilol combined with L- carnitine（C＆L） treatment group. In addition, normal control group （5 cases） was made. Left ventricular end - diastolic dimension （ LVEDD）, left ventricular end - systolic dimension（LVESD） , ventricular weight（VW） and body weight（BW） were determined, FFA in plasma was determined with colorimetry and CGRP in plasma was determined with radioimmunoassay method. Results The function of left ventricular was declined, the plasma level of CGRP in CHF groups was decreased remarkably and the plasma level of FFA was increased obviously. There were significant differences in LVEDD, LVESD, BW and VW among groups. The plasma level of CGRP in L - CN group, Car group and C＆L group were increased remarkably when compared with CHF group, while the level of FFA was declined and there were significant difference between L＆C group and L - CN, CAR group. Conclusion The plasma level of CGRP was increased and that of FFA was decreased by L - CN, Carvedilol and united apphcation, and relax HF and myocardial remodeling.

关 键 词：充血性心力衰竭 L-卡尼汀 卡维地洛 降钙素基因相关肽 

分 类 号：R541.61[医药卫生—心血管疾病]