缺碘缺锌对发育期大鼠脑脂类代谢的影响  

Effect of combined iodine and zinc deficiency of lipid metabolism of rat brain in postnatal developing stage

作　　者：王丹娜[1] 辛镇祓 陈秀洁[1] 石玉霞[3] 李德安[4] 冯杰[4] 刘守军[1] 

机构地区：[1]哈尔滨医科大学地甲病研究所,150086 [2]深圳人民医院 [3]哈尔滨医科大学地氟病所,150086 [4]哈尔滨医科大学大骨节所,150086

出　　处：《中国地方病学杂志》1997年第5期279-282,共4页Chinese Jouranl of Endemiology

基　　金：国家自然科学基金;项目号 39270609

摘　　要：按2×2析因实验设计将 Wistar 大鼠分成四组:加碘加锌组、加碘缺锌组、缺碘加锌组、缺碘缺锌组(缺碘组饲料中含甲基硫氧嘧啶 MTU)。观察了碘和锌两种因素及其联合作用对生后15、30日龄仔鼠大脑总脂质、总磷脂及总胆固醇含量的影响。结果表明,缺碘和缺锌都影响脑内上述三种物质的合成,表现为两个缺碘组其含量明显低于加碘加锌组,而且在碘水平正常的情况下,缺锌也能产生缺碘样作用。经方差分析碘锌之间存在交互作用。上述结果提示碘和锌在维持脑的内环境稳定上有多种重要功能,尤其是在脑发育期缺碘或缺锌都能影响脑的正常发育,是造成脑脂类合成下降及脑髓化代谢障碍的主要原因。Wistar rats were randomly divided into four groups based on 2×2 factorial design.The effects of iodine,zinc and their combined deficiency on lipid metabolism of the brain were studied at 15 and 30th day after birth.The results suggested the iodine and zinc had a lot of importment role in keeping stabi- lization of internal environment of human body,espically the stage of brain development,the deficiency of iodine and zinc elements could cause a downward tendency in lipid synthesis retardation of myelina- tion.

关 键 词：碘 锌 脑发育 脂类 微量元素缺乏病 

分 类 号：R591.1[医药卫生—内科学]