鼠脑铝含量分析及其学习记忆改变的研究  

A studies on the aluminium content analysis of rats brain and the change of memory

作　　者：钱亦华[1] 胡海涛[1] 杨杰[1] 王唯析[1] 牛映斗[1] 张樟进[1] 胡小丹 

机构地区：[1]西安医科大学人体解剖学教研室

出　　处：《微量元素与健康研究》1997年第3期1-2,共2页Studies of Trace Elements and Health

基　　金：国家自然科学基金

摘　　要：将大鼠分成ＡｌＣｌ３与空白对照两组。前者每日用ＡｌＣｌ３灌胃。均先做避暗回避试验，用原子吸收光谱法测定铝含量。结果：①行为测验，ＡｌＣｌ３组在给铝盐前后受电击次数及潜伏期分别呈增多和缩短，且与对照组间有显著性差异（Ｐ＜０．０１）；②ＡｌＣｌ３组脑内铝含量明显高于对照组（Ｐ＜０．０５）。说明高铝饮食可引起铝元素在脑内的异常蓄积，同时导致记忆力减退。Rats were divide into aluminium chiorid group and contral group,the former was pretreated with aluminium chirid PO every day.At begaining all rats were done with one trial passive avoidence responses.Aluminium content was assaied.Results:1.Behavour test,the times of electrification in aluminium chlorid group have increased,the mean altency of electrification have induced and there were prominent differences in comparison with contral group(P<0 01).2.aluminium content of hippocampal formation and neocortex region were higher significantly in the aluminium chlorid group than contral group(P<0.05).So the results suggest that rich aluminium food cause aluminium deposition in brain and memory deficts.

关 键 词：铝 学习记忆 早老性痴呆 微量元素 异常蓄积 

分 类 号：R595.2[医药卫生—内科学] R749.16[医药卫生—临床医学]