心肌机能指数和血浆脑钠肽评估心力衰竭的临床研究  

Tei index and B-type natriuretic peptide in assessment of systolic and diastolic heart failure

作　　者：张高星[1] 张学芳[1] 陈彪[1] 赖兆新[1] 林如明[1] 彭宇程[1] 高伟栋[1] 任强[1] 赖浚兴[1] 宋岸坚[1] 孙炎华[1] 

机构地区：[1]中山大学附属江门医院心血管内科,广东江门529070

出　　处：《中国心血管杂志》2008年第3期195-198,共4页Chinese Journal of Cardiovascular Medicine

摘　　要：目的探讨超声指标——心肌机能指数(Tei)与血浆脑钠肽(BNP)水平鉴别收缩性心力衰竭(SHF)及舒张性心力衰竭(DHF)的临床应用价值。方法入选心力衰竭患者67例,按照左室射血分数(LVEF)分为SHF(LVEF<50%)及DHF组(LVEF≥50%)。32名健康者为对照组,测常规超声指标及Tei指数,并采用ELISA法测得血浆BNP水平。结果与对照组相比,DHF及SHF组Tei指数、BNP显著增高(P<0.01);心力衰竭两组相比,Tei指数、BNP在SHF组显著升高(0.63±0.11)比(0.82±0.20)ng/L,P<0.01;713.38ng/L比1345.86ng/L,P<0.05,且二者呈显著正相关(r=0.71,P<0.01)。结论Tei指数、BNP在心力衰竭患者显著升高,二者可鉴别SHF及DHF。Objective To determine the significance of identifying systolic and diastolic heart failure （HF）. Tei index and plasma B-natriuretic peptide （BNP） level in Methods Thirty-two healthy individuals and sixty-seven HF patients were included. Echocardiography and neurohormonal analysis were performed. Results Compared to the control group, Tei index, BNP level were much higher in both systolic and diastolic HF patients （P〈0.01）. Tel index and BNP level were higher in systolic HF patients than diastolic HF patients （0.63±0.11 vs 0. 82±0. 20）ng/ L, P〈0.01; 713. 38 ng/L vs 1345. 86 ng/L, P〈0. 05）. Correlation between Tel index and BNP level was significant （r= 0. 71, P〈0. 01）. Conclusions Tei index and BNP level are useful in differencing systolic and diastolic HF.

关 键 词：心肌 利钠肽 脑 临床对照试验 

分 类 号：R541.6[医药卫生—心血管疾病]