1992～1995年中国瑞丽等地吸毒人群艾滋病病毒感染率观察及定群研究  

A Cohort Study of HIV Infection Among Intravenous Drug Users in Ruili and Other Two Counties in Yunnan Province, China, 1992-1995

作　　者：郑锡文[1] 张家鹏[2] 曲书泉[1] 程何荷[2] 李大勤[1] 贾曼红[2] 张桂云[1] 段松 田春桥[1] 段一娟 陈艳麟 李志荣 

机构地区：[1]中国预防医学科学院流行病学微生物学研究所,北京102206 [2]云南省卫生防疫站 [3]云南省德宏州,瑞丽市,陇川县卫生防疫站

出　　处：《中华流行病学杂志》1997年第5期259-262,共4页Chinese Journal of Epidemiology

摘　　要：对1992年起在中国西南边境瑞丽等县建立的吸毒人群HIV感染率及发病率观察的现场,每年进行追踪调查,1992～1995年历年各调查859、437、343及540名,共2 179名。3县吸毒人群中静注者比例约为30%。1995年上升至近50%。瑞丽县静注毒品者HIV感染率较高,1992～1995年历年为81.8%、85.7%、61.8%及51.9%;陇川县居中。历年为44.6%、40.0%、42.4%及43.5%;潞西县一直维持较低水平,历年为5.1%、0%、0%及3.1%。1992～1995年瑞丽静注毒品者中HIV抗体阴性者的发病率(每百人年)较高,为21.7%～42.1%,平均30.1%;陇川次之,为12.1%～25.9%,平均17.2%;潞西较低,为0%～2.3%,平均为0.6%。3县HIV感染者的配偶的感染率1990年为3.1%,1992～1995年为9.8%、7.4%、0%及10.3%,1997年为12.3%。对107名HIV感染者CD_4细胞测定表明,感染年份越早,CD_4细胞计数<500/mm^3者所占的比例越高。对29名用NASBA法测定病毒载量(Viral load)。其中3名<1 000拷贝/ml,其余26名的病毒载量对数(10g)平均值为4.37。Since 1992, cohort study of prevaienee of HIV infection and incidence rate among drug users has been conducted annually at the study spots along southwestern border areas of Ruili, Longchuan and Luxi counties, Yunnan province of China. From 1992 to 1995, 859,437,343 and 540 drug users with a total number of 2179 cases were studied respectively. The proportion of IDUs among drug users was about 30% in 1992, and went up to about 50% in 1995. HIV serloprevalence rates among IDUs in Ruili was comparatively high. From 1992 to 1995, the rates were 81.8%, 85.7%, 61.8% and 51.9% respectively. Longchuan county was at medium, 44.6%, 40.0%, 42.2% and 43.5% respectively. Luxi kept at a lower level, which were 5.1%, 0%, 0% and 3.1%. From 1992 to 1995, the increase of incidence rates were 30.1% from 21.7% to 42.1% in Ruili county, 17.2% (12.1% to 25.9%) in Long Chuan, and 0.6% (0% to 2.3%) in Luxi. The sero-prevalence rate among the spouses of these HIV infected persons was 3.1% in 1990, but increased to 9.8%, 7.4%, 0% and 10.3% respectively from 1992 to 1995 and was 12.3% in 1997. CD_4 counting was conducted in 107 cases. The result indicated at the earlier of the year being infected. The higher proportion of CD_4 count which was <500/mm^3 on NASBA was applied to analyse the viral load, 3 out of 29 cases were<1000 copies/ml, while Log mean of viral load in 26 cases was 4.37.

关 键 词：艾滋病 病毒 静注毒品者 感染率 发病率 吸毒 

分 类 号：R512.91[医药卫生—内科学]