The Effects of Folium Perillae Extract on Blood Fat and Lipid per Oxidation of Rabbit with Hyperlipemia  

紫苏叶提取物对高脂血症家兔血脂及脂质过氧化的影响（英文）

作　　者：谭健民[1] 陈眷华[1] 徐在品[1] 霍欣[1] 邓小燕[2] 张迪[1] 简秀华 

机构地区：[1]贵州大学动物科学学院动物医学系,贵州贵阳550025 [2]北京航空航天大学生物工程系,北京100083 [3]贵阳市花溪农业局,贵州贵阳550025

出　　处：《Agricultural Science & Technology》2008年第1期121-124,共4页农业科学与技术（英文版）

基　　金：Supported by the National Natural Science Foundation of China(10572029,1063201,10772054)~~

摘　　要：[Objective] The preventive and therapeutic effects of Folium perillae extract （FPE） on hyperlipemia induced by feeding rabbit with high fat forage were observed. [Method] The high fat and cholesterol diet were adopted to create the hyperlipemia model of rabbit. The rabbits were randomly and equally divided into 5 groups which were NC（ normal control）group, HLM （high lipid model） group, LFPE, MFPE and HFPE group （low, middle, high dosage of FPE were 0.17 g/kg, 0.5 g/kg and 1.5 g/kg respectively）. The contents of TC, TG, LDL-C, HDL-C, MDA and the activity of SOD in serum were detected respectively. [ Result] The three FPE groups could decrease the contents of TC, TG, LDL-C, MDA significantly （P〈0.01） compared with these of HLM group, and the contents of HDL-C （P〈0.01） and the activity of SOD （P〈0.05 ） in serum was increased significantly. [Conclusion] FPE could regulate blood-fat and counteract lipid peroxidation.紫苏具有良好的抗氧化作用，但大部分研究只局限于体外实验，有关调节血脂方面的研究则鲜有报道，并且研究主要是集中在紫苏籽油上。对于紫苏叶是否具有抗高脂血症及脂质过氧化方面的研究还未见报道。为此，笔者从已有的理论基础出发．对紫苏叶提取物调节血脂及抗脂质过氧化的方面作用进行研究。

关 键 词：Folum perillae extract（FPE） Blood fat Malonaldehyde（MDA） Superoxide dismutase（SOD） 

分 类 号：S858.291[农业科学—临床兽医学]