不同剂量心肌肽抗小鼠运动性疲劳的研究  

Research of Various Dosage Carnosine Affecting on Anti-Fatigue of motility for Rats

作　　者：高淑杰[1] 吴丹[1] 

机构地区：[1]沈阳体育学院生理生化教研室,辽宁沈阳110102

出　　处：《广州体育学院学报》2008年第3期90-92,共3页Journal of Guangzhou Sport University

基　　金：辽宁省教育厅科学技术研究项目课题。项目批准号:2005411

摘　　要：探讨了不同剂量心肌肽对小鼠运动能力的影响。分别以0.12mg/gBW.d(低剂量)、0.23mg/gBW.d(中剂量)、0.69mg/gBW.d(高剂量)的心肌肽给予小鼠连续灌胃20d,对照组灌蒸馏水0.2(ml/d)。20天后测定小鼠力竭游泳时间、血红蛋白(Hb)、血乳酸(BLA)、血尿素(BUN)含量。结果显示:中剂量组、高剂量组均能延长小鼠的负重游泳时间,降低血乳酸、血尿素的含量,提高体内血红蛋白的储备量。提示:心肌肽具有抗疲劳和提高机体运动能力的功效,其效果具有剂量反应关系。This paper investigates the effect of various dosage carnosine on the movement ability of rats. The carnosine fill into rats＇ stomach at the dosage of 0.12mg/gBW.d, 0.23mg/gBW.d and 0.69mg/gBW.d for 20 continuous days respectively. The control group given distilled water （0.2ml/d） by gastric perfusion. The exhausted swimming time, hemoglobin （Hb）, blood lactic acid （BLA） and blood urea nitrogen （BUN） concentration after 20 days. The result shows that two dosages both could prolong swimming time of rats, decrease BLA and BUN, and increase Hb. From the observation, we can conclude that carnosine has the function of anti-fatigue and increasing movement ability, and its effects existing dosage-response association.

关 键 词：心肌肽 血乳酸 血尿素 血红蛋白 抗疲劳 

分 类 号：G804.7[文化科学—运动人体科学]