热毒清口服液对内毒素性发热家兔体温及血浆一氧化氮的影响  

Effects of Reduqing Oral Liquid on Body Temperature and Plasma Nitric Oxide Level in Rabbits with Endotoxic Induced Fever

作　　者：周大勇[1] 张宗铭[1] 韩宁林[1] 李雪苓[1] 陈双萍[1] 范泉[1] 王凯[1] 代君[1] 

机构地区：[1]安徽中医学院第一附属医院,安徽合肥230031

出　　处：《中国中医药信息杂志》2008年第7期35-37,共3页Chinese Journal of Information on Traditional Chinese Medicine

基　　金：安徽省教育厅自然科学基金(2003KJ231)

摘　　要：目的观察热毒清口服液(热毒清)对内毒素性发热家兔的体温以及血浆一氧化氮(NO)水平的影响,并比较不同剂量的药效。方法采用内毒素注射的方法制成发热家兔模型,将60只家兔随机分为6组:复方乙酰水杨酸组、热毒清高剂量组、热毒清中剂量组、热毒清低剂量组、双黄连口服液组、模型组,每组10只,观察比较各组体温变化及血浆NO水平。结果与模型组比较,热毒清中剂量组及高剂量组对发热家兔的体温有明显的降低作用,且比复方乙酰水杨酸组解热作用时间延长;热毒清低剂量组及双黄连组对发热家兔的体温无明显作用;热毒清高剂量组治疗后4h的血浆NO水平显著低于模型组。结论热毒清高剂量及热毒清中剂量能够降低内毒素性发热家兔的体温,降低血浆NO水平。Objective To investigate the effects of Reduqing Oral Liquid （RDQ） on endotoxic fever and plasma nitric oxide （NO） levels of rabbits. Methods Sixty rabbits were randomly divided into 6 group： Acetylsalicy Acid （APC） group, RDQ high dosage group, RDQ low dosage group, RDQ middle dosage group, Shuanghuanglian （SHL） group, model group, ten rabbits of each group. Body temperature and plasma NO of each group were observed. Results In RDQ high dosage group and middle dosage group, plasma NO and fever were reducedsignificantly （P〈0.05） compared with the model group and longer than APC group. RDQ low dosage group and SHL group had no significant effect of reducing fever. Conclusion High and middle dosage of RDQ can reduce the fever and decrease the plasma NO in rabbits with endotoxic fever.

关 键 词：热毒清口服液 内毒素性发热 一氧化氮 家兔 

分 类 号：R285.5[医药卫生—中药学]