登革热患者横纹肌损害的血清酶学变化特征  

Features of seroenzyme vairations of lesions in striated muscle of dengue fever cases

作　　者：杨斌[1] 黄日皎[1] 陈红涛[1] 

机构地区：[1]中山大学附属第五医院检验科,广东珠海519000

出　　处：《中国热带医学》2008年第7期1128-1129,共2页China Tropical Medicine

摘　　要：目的分析登革热患者横纹肌损害的血清酶学变化特征,提示患者有无早期心肌损害。方法回顾性分析2007年中山大学附属第五医院收治的住院登革热患者108例实验室检查资料。结果108例患者登革热IgM抗体阳性率100%,核酸检测显示感染病毒类型是DEN-Ⅰ型,血清天门冬氨酸转氨酶(AST)、乳酸脱氢酶(LDH)、肌酸磷酸激酶(CK)及β-羟丁酸(β-HBD)水平高于参考值上限分别占79.6%、80.6%、43.5%和69.4%;外周血血小板及白细胞计数低于参考值下限分别占82.4%和85.2%。结论部分患者有不同程度的心肌损害,经积极治疗效果较好,但血清酶学恢复较慢。Objective To analyze the seroenzyme characteristics of rhabdium lesions in patients with dengue fever,and make early detection of cardiac muscle injury.Methods Laboratory data of 108 patients with dengue fever were retrospectively analyzed.Results 100% of 108 cases were seropositive to dengue virus and dengue viral serotypeⅠ（DEN-Ⅰ） was confirmed by RT-PCR test.The serum levels of aspartate aminotransferase（AST）,lactase dehydrogenase（LDH）,creatinine kinase（CK） and beta-hydroxybutyric acid（β-HBD） which were above normal range accounted for 79.6%,80.6%,43.5% and 69.4%.The blood counts of thrombocyte and leucocyte below normal range were accounted for 82.4% and 85.2%.Conclusion Cardiac muscle lesions are observed in some patients with various extent and the therapeutic effect is satisfactory,but the seroenzyme levels recovered slowly.

关 键 词：登革热 横纹肌 血清酶 

分 类 号：R512.8[医药卫生—内科学]