核素心室造影检测系统性红斑狼疮左室功能的价值  

Value of radionuclide ventriculography in detecting left ventricular function of SLE patients

作　　者：饶国辉[1] 刘生[2] 李洁明[1] 吴克宁[1] 李纬明[1] 李春亿[1] 

机构地区：[1]中山大学附属第一医院核医学科,广东广州510080 [2]中山大学附属第二医院核医学科,广东广州510120

出　　处：《中国热带医学》2008年第7期1150-1151,1176,共3页China Tropical Medicine

摘　　要：目的探讨核素心室造影检测系统性红斑狼疮(SLE)患者左室功能的应用价值。方法对40例SLE患者和15例正常人进行核素心室造影。结果SLE患者左室收缩功能参数,如左室射血分数(LVEF)、高峰射血率(PER)和前1/3射血分数(1/3EF)与对照组比较,差异均无显著性意义(P>0.05),仅1/3ER比对照组降低,差异有极显著性意义(P<0.01)。但患者舒张功能参数如高峰充盈率(PFR)、前1/3充盈率(1/3FR)、前1/3充盈分数(1/3FF)均降低,差异有显著性意义(P<0.05),且活动期降低更明显。患者左室相位标准差(LVSDP)增大,提示心肌收缩运动协调性降低。对13例非活动期患者和27例活动期患者进行了运动核素心室造影,两组患者运动状态左心收缩功能和舒张功能参数与静息状态比较均有改变,差异有显著性意义(P<0.05)。结论核素心室造影可以客观评价SLE患者左心室功能,在检测SLE心脏受累中具有一定的临床价值。Objective To investigate left ventricular function in patients with systemic lupus erythematosus（SLE）.Methods There forty patients with clinically active（n=27）,inactive（n=13） systemic lupus erythematosus and healthy controls（n=15） were examined by radionuclide ventriculography.Results The left ventricular（LV） systolic function paramenters such as LVEF,1/3EF and PER were not significantly statisticaldifference as compared with that of healthy controls.LV diastolic function parameters,including peak filling rate（PFR）,filling fraction of the first third diastolic（1/3FF）and filling rate of the first third（1/3FR） decreased statistically in patients with SLE（P〈0.05）,especially in active stage.Standard deviation of the peak（SDP） of LV in patients increased.13 SLE-ID patients and 27 SLE-AD patients were conducted by radionuclide ventriculography in exercise tolerance condition.Both groups of patients in exercise condition were experienced a decline in left ventricular（LV） systolic function and LV diastolic function.Conclusion Radionuclide ventriculography can be used to evaluate cardiac function in SLE patients and thereby helpful for the diagnosis of the myocardial damage in the disease.

关 键 词：系统性红斑狼疮 放射性核素心室显像术 左心室功能 

分 类 号：R593.241[医药卫生—内科学]