2,6-二氯-5-氟-3-甲酸吡啶的合成  

Study on the synthesis of pyridine 2,6-dichloro-5-fluoro-3-carboxylic acid

作　　者：谭珍友[1] 刘安昌[1] 肖庆[1] 刘芳[1] 

机构地区：[1]武汉工程大学湖北省新型反应器与绿色工艺重点实验室,湖北武汉430074

出　　处：《化学试剂》2008年第1期35-36,42,共3页Chemical Reagents

摘　　要：以氟乙酸乙酯、甲酸乙酯和氰基乙酰胺为原料,在甲醇钠的催化下经环化得到2,6-二羟基-5-氟-3-氰基吡啶,然后经PCl5/POCl3氯化和水解得到了标题化合物,总收率43.7%。A improved process for the preparation of pyridine 2,6-dichloro-5-fluoro-3-carboxylic acid was described where 2,6-dihydroxy-3-cyanc-5-fluoropyridine was prepared using ethyl formate, ethyl fluoroacetate and cyanoacetamide as the starting materials in the presence of sodium methoxide as the catalyst, then the resulted product was converted in one step using phosphorus oxychloride and phosphorus pentachloride in the presence of triethylamine into 2, 6-dichloro-3-cyano-5-fluoropyridine, which after subsequent acid hydrolysis gave pyridine 2,6-dichloro-5-fluoro-3-carboxylic acid with an overall yield of 43.7% .

关 键 词：2 6-二氯-5-氟-3-甲酸吡啶 PCl5/POCl3氯化 水解 

分 类 号：O626.32[理学—有机化学]