头孢曲松钠与茜素的光度分析及应用  

The spectrophotometry of ceftriaxone sodium with alizarin and analytical applications

作　　者：殷黄林[1] 何丽平 江虹[1] 

机构地区：[1]长江师范学院化学及环境科学系,重庆408100 [2]重庆市涪陵区计量质量检测中心,重庆408000

出　　处：《化学试剂》2008年第1期46-48,共3页Chemical Reagents

基　　金：重庆市教委科技基金资助项目(KJ051304)

摘　　要：建立了测定头孢曲松钠的茜素分光光度法。在pH6．5～9．0的条件下，茜素（ALZ）与头孢曲松钠（CEFT）反应生成具有正、负吸收峰的红色配合物，最大正吸收波长位于535nm，表观摩尔吸光系数ε为1．87×10^4L·mol^-1·cm^-1，线性范围为0．2～9．2mg／L；最大负吸收波长位于445nm，表观摩尔吸光系数（ε）为4．8×10^3L·mol^-1·cm^-1，线性范围为0．2～8．3mg／L。头孢曲松钠在一定浓度范围内遵从朗伯比尔定律。探讨了适宜的反应条件、主要分析化学性质及配合比。该法用于实际样品的测定，结果满意。A new spectrophotometric method for the determination of ceftriaxone sodium has been developed. Under a condition of pH 6.5 - 9.0, alizarin （ALZ） could react upon ceftriaxone sodium（CEFT） to form red complexes with an obvious positive absorption peak and an negative peak. The maximum positive absorption wavelength was at 535 nm and the apparent molar absorptivities（ε） was 1.87 × 10^4 L·mol^- l·cm^-l, with the linear range equating to 0.2 -9.2 mg/L. The maximum negative absorption wavelength was at 445 nm, the apparent molar absorptivities（ε） was 4.8 × 10^3 L·mol^-1·cm^-1, and the linear range was from 0.2 mg/L to 8.3 mg/L. Ceftriaxone sodium obeys Lombard Beer＇s law in a definite concentration range. The optimum reaction conditions, the main chemical properties and the compound ratio were studied. The method was applied to determine the content of ceftriaxone sodium in the actual samples with satisfactory results.

关 键 词：头孢曲松钠 茜素 分光光度法 

分 类 号：O657.32[理学—分析化学]