岩白菜素两个衍生物的合成及镇痛活性研究  

Study on Preparation of Two Derivatives of Bergenin and Their Analgesic Activity

作　　者：张韶湘[1] 赵永娜[1] 赵庆[2] 邹澄[1] 孙科[1] 王继良[1] 

机构地区：[1]昆明医学院药学院,昆明650031 [2]云南中医学院,昆明650200

出　　处：《天然产物研究与开发》2008年第3期527-529,共3页Natural Product Research and Development

基　　金：云南省应用基础研究计划面上项目(2006C0045M)

摘　　要：本文研究两个岩白菜素衍生物的合成及其镇痛活性。以岩白菜素为原料,通过选择性磺酰化和曼尼希反应各自得到一个产物.采用小鼠扭体法检测两个化合物的镇痛活性。两个化合物分别在剂量为60mg/kg,100mg/kg时可明显抑制小鼠扭体次数,试药组与生理盐水组比较差异具有显著性意义(P<0.05)。对比两衍生物的结构提示镇痛活性可能与岩白菜素的基本骨架有关。This paper studied the preparation of two derivatives of bergenin and their analgesic activity. Selective sulfony-lation and Mannich reaction of bergenin were carried out respectively and two derivatives were obtained. Two products＇analgesic effects were observed by employing the writhing test in mice. Two products significantly inhibited the writhing responses of mice with dose 60,100 mg/kg respectively. Comparison of the structures of the two derivatives indicated that the analgesic activity may be caused by their nuclear parent.

关 键 词：岩白菜素 衍生物 镇痛 

分 类 号：Q946[生物学—植物学] R284.3[医药卫生—中药学]