定向碳纳米管修饰电极测定氧氟沙星  

Electrochemical Determination of Ofloxacin Using Electrode Modified with Aligned Carbon Nanotubes

作　　者：吴芳辉[1] 朱静[1] 何孝军[1] 

机构地区：[1]安徽工业大学化学与化工学院,马鞍山243002

出　　处：《应用化学》2008年第7期792-796,共5页Chinese Journal of Applied Chemistry

基　　金：安徽省高校青年教师基金(2005JQ1076);安徽省煤的洁净转化与综合利用重点实验室基金;安徽工业大学SRTP资助项目

摘　　要：研究了氧氟沙星在定向碳纳米管修饰电极上的电化学行为。结果发现，修饰电极对氧氟沙星有优良的电催化作用。使得氧氟沙星在修饰电极上的氧化峰电位比在裸玻碳电极上明显负移，氧化峰电流显著提高。优化了反应介质、富集时间、修饰剂用量、扫描速率等测定参数。研究发现，氧氟沙星浓度在8．0×10^-7-2．0×10^-2mol／L之间与峰电流呈良好的线性关系，检出限为3．2×10^-7mol／L。一些常见的离子和生物物质不干扰氧氟沙星的测定。氧氟沙星平行测定10次的相对标准偏差（RSD）为4．2％。用该修饰电极测定氧氟沙星滴眼液中氧氟沙星的含量，结果令人满意。The electrochemical behavior of ofloxacin at glassy carbon electrode（GCE） modified with aligned carbon nanotubes （ACNTs） was investigated. The results showed the oxidation peak current of ofloxacin increased significantly at the ACNTs-modified GCE in comparison with that at bared GCE. The experiment parameters such as the type and acidity of the electrolyte, the accumulation time, the thickness of the ACNTs- modified layer and scan rate were optimized. Linear correlation between the oxidation peak current and the concentration of ofloxacin was found over a range from 8.0 × 10^-7 to 2. 0 × 10^-3 mol/L with a detection limit of 3.2 × 10^-7 mol/L. In 0. 1 mol/L Britton-Robinson buffer solution（pH 7.0）, the presence of a lot of metal ions and ascorbic acid and urin etc did not interfere with the determination of ofloxacin. The relative standard deviation（RSD） of ten measurements was 4. 2% for ofloxacin, indicating good reproducibility. This method was used to determine the ofloxacin concentration in real ofloxacin samples with good results.

关 键 词：氧氟沙星 定向碳纳米管 化学修饰电极 

分 类 号：O657.1[理学—分析化学]