氨基磺酸催化无溶剂一锅法合成α-氨基膦酸酯  

One-pot synthesis of α-Amino Phosphonates Under Solvent-free Conditions Catalyzed by Sulfamic Acid

作　　者：陈伟华[1] 李维思[1] 李振江[1] 

机构地区：[1]南京工业大学制药与生命科学学院,南京210009

出　　处：《应用化学》2008年第7期859-861,共3页Chinese Journal of Applied Chemistry

基　　金：国家"九七三"计划资助项目(2007CB74305)

摘　　要：利用廉价、低毒、易于处理的氨基磺酸作为Lewis酸催化剂,在无溶剂,室温条件下,催化羰基化合物,胺及亚磷酸二乙酯反应,一锅法合成了α-氨基膦酸酯。合成了7个目标化合物,通过1H NMR分析确定了结构。产物最终收率均超过80%。此方法温和,简单,安全,易于操作,催化剂氨基磺酸在反应结束后经简单处理可以回收再利用。α-Amino phosphonates were one-pot synthesized from carbonyl compound, amines, diethylphosphite with the inexpensive, nontoxic and readily available sulfamic acid as Lewis acid catalyst. The syntheses were carried out under solvent-free conditions at ambient temperature. Seven products were given and the structures of target compounds were confirmed by ^1H NMR. The overall yields of the products were all above 80%. This method was mild, simple, safe and easily manipulated. After the reaction was completed, the catalyst of sulfamic acid could be recovered after simple treatment and could be used for next cycle.

关 键 词：虱基磺酸 α-氨基膦酸酯.亚磷酸二乙酯 

分 类 号：O621.3[理学—有机化学]