厄贝沙坦和卡托普利对社区心血管病患者心脏储备功能的影响  

EFFECTS OF IRBESARTAN AND CAPTOPRIL ON THE CARDIAC RESERVE OF CARDIOVASCULAR PATIENTS FROM COMMUNITY

作　　者：刘天虎[1] 曾洪燕[1] 晏明君 许锋成 尹小华[1] 陈容[1] 肖守中[2] 

机构地区：[1]四川郫县人民医院,郫县611730 [2]重庆大学生物医学工程系

出　　处：《现代预防医学》2008年第13期2526-2527,2545,共3页Modern Preventive Medicine

基　　金：国家自然科学基金资助项目(30070211)

摘　　要：[目的]了解厄贝沙坦和卡托普利对左心室功能和心脏储备功能的影响。[方法]对80位社区心血管病患者随机分为厄贝沙坦组和卡托普利组治疗6个月,治疗前后应用超声心动图(UCG)测定左室舒张末期内径(LVDd)、舒张末期室间隔厚度(IVSd)、舒张末期左室后壁厚度(LVPWd)、左室射血分数(LVEF)、二尖瓣舒张早期最大峰值流速E峰(VE)和舒张晚期最大峰值流速A峰(VA)、左心室心肌重量(LVM),应用心音图运动试验(PCGET)测定运动前后第一心音幅值(S1),运动前后心率、6min步行试验步行的距离、心力储备指数(CCRI)和心脏储备指数(CRI)。[结果]治疗前后比较,两组IVSd及LVPWd较前明显减少(P﹤0.05),LVEF明显增加(P﹤0.05),LVM明显下降(P﹤0.01),静息心率下降和运动后心率增加(P﹤0.05),6min步行距离增加(P﹤0.05),CCRI和CRI明显增加(P﹤0.01)。[结论]厄贝沙坦和卡托普利均能改善左心室收缩功能和舒张功能,逆转左心室重塑,增加运动能力,CRI增加,改善心脏储备功能,且疗效相似,药物价格低廉,适合社区心血管病患者使用。[Objective] To know the effects of irbesartan and captopril on the left ventricular function and cardiac reserve. [ Methods] Eighty cardiovascular patients from community were randomly divided into irbesartan group and captopril group and treated for 6 months. Left ventrieular end-diastolic internal dimension （LVDd）, end-diastolic interventricular septum thickness （IVSd）, end-diastolic posterior LV wall thickness （LVPWd）, LV ejection fraction （LVEF）, peak early diastolic mitral flow velocity （VE） and peak late diastolic mitral flow velocity （VA）, and left ventrieular mass （LVM） were measured by ultrasound cardiogram （UCG） before and after treatment. The amplitude of the first heart sound （S1） and heart rate （HR） before and after exercise, distance for 6-min walking test, cardiac contractility reserve index （CCRI）, and cardiac reserve index （CRI） were measured by phonocardiogram exercise test. [ Results] IVSd and LVPWd significandy decreased than before treatment （P 〈 0.05）, LVEF significantly increased （P 〈 0.05）, LVM significantly decreased （P 〈 0.01 ）, rest HR decreased and HR after exercise increased （P〈 0.05）, distance for 6-rain walking test increased （P〈 0.05）, CCRI and CRI significantly increased （P 〈 0.01 ）. [Conclusion] Both irbesartan and captopril can improve left ventricular contraction and relaxation function, reverse LV remodeling, enhance exercise capacity, increase CRI, improve cardiac reserve, and both drugs are of similar effects, low-cost, suitable for use in the cardiovascular patients from community.

关 键 词：厄贝沙坦 卡托普利 心脏储备 

分 类 号：R54[医药卫生—心血管疾病]