饮酒成年男子红细胞免疫状态与超氧化物歧化酶和过氧化脂质关系的研究  

STUDY ON THE RELATIONSHIP BETWEEN THE CHANGE OF ERYTHROCYTE IMMUNE STATE AND THE LEVELS OF SOD AND LPO IN DRINKING ADULT MEN

作　　者：李沛[1] 扈美庄[1] 何新萍[1] 陈灿[2] 吴平[3] 

机构地区：[1]广东医学院预防医学教研室,湛江524023 [2]广东医学院附属医院内科 [3]广东医学院附属医院中心实验室

出　　处：《现代预防医学》2008年第13期2587-2588,2590,共3页Modern Preventive Medicine

摘　　要：[目的]探讨饮酒者体内红细胞免疫状态改变,以及其与超氧化物歧化酶和过氧化脂质的关系。[方法]对饮酒组(118人)和非饮酒对照组(53人)健康成年男子分别检测其红细胞受体花环率(RBC-C3bRR)、红细胞免疫复合物花环率(RBC-ICR)、红细胞超氧化物歧化酶(SOD)以及血浆过氧化物脂质(LPO)的变化。[结果]饮酒组的RBC-C3bRR、SOD水平均显著低于非饮酒对照组,而RBC-ICR、LPO水平则显著高于非饮酒对照组;相关分析表明SOD水平随着饮酒量的增加而下降,两者呈负相关关系(r=-0.725,P﹤0.01),而LPO则随饮酒量的增加而增高,两者呈正相关关系(r=0.916,P﹤0.01);直线相关回归分析表明RBC-C3bRR与SOD呈正相关(r=0.657,P﹤0.05),而与LPO呈负相关(r=-0.872,P﹤0.01),RBC-ICR与LPO呈正相关关系(r=0.617,P﹤0.05)。[结论]饮酒可引起继发性免疫功能低下,其可能与体内的超氧化物歧化酶相对不足及过氧化物脂质增加有关。[Objective] To examine relationship between the change of erythrocyte immune state and the levels of SOD and LPO in drinking people. [ Methods] The levels of red blood cell C3b receptor （RBC-C3bRR）, red cell blood immune complex rosette （RBC-ICR）, superoxide dismutase （SOD） and lipid peroxide （LPO） were determined in two groups which were drinking group （118 cases healthy adult men） and non-drinking control group （42 cases healthy adult men）. [Results] RBC-C3bRR and SOD in the drinking group were markedly lower comparing with those of the non-drinking group （P 〈 0.01, P 〈 0.05）, while RBC-ICR and LPO were significantly increased （P 〈 0.05, P 〈 0.01）, Furthermore, the correlation analysis showed that there was a significantly negative correlation between SOD and the drinking quantity （r = -0.725, P 〈 0.01）, which was a significantly positive correlation between serum LPO and the drinking quantity （r = 0.916, P 〈 0.01 ）. In addition, the RBC-C3bRR was positively related to SOD （r = 0.657, P〈 0.05）, but negatively to LPO （r = -0.872, P〈 0.01）, and RBC-ICR was positively related to LPO （r = -0.716, P 〈 0.05）. [Conclusion] Erythrocyte immune in drinking people is decreased, which is in relation to the decrease of erythrocyte SOD and the increase of LPO.

关 键 词：饮酒者 红细胞免疫 超氧化物歧化酶 过氧化物脂质 

分 类 号：R87[医药卫生—运动医学] R392.12[医药卫生—临床医学]