爆轰塔内爆震伤对犬病理生理及早期血液流变学变化的影响  

Changes on the pathophysiological effects and the parameters of hemorrheology after indoor blast injuries to the dogs

作　　者：朱长亮[1] 韩勇[1] 张志培[1] 钟代星[1] 赵亚超[1] 程庆书[1] 

机构地区：[1]第四军医大学唐都医院胸外科,陕西西安710038

出　　处：《创伤外科杂志》2008年第4期352-355,共4页Journal of Traumatic Surgery

基　　金：军医药卫生科研基金资助(06M264)

摘　　要：目的探讨室内爆炸产生的冲击波对实验犬病理生理及早期血液流变学的影响。方法健康成年犬24只,按照炸药质量及爆炸源距实验犬距离随机分为A、B、C致伤组和无致伤对照组(n=6)。爆轰塔内致伤后按1、3、5、12小时4个时相点观察呼吸、心率、血压变化、动脉血气、血液流变学指标及心脏病理改变。结果伤后呼吸、心率、血压及动脉血气变化较对照组均有显著统计学意义(P<0.05)。全血黏度(WBV)、红细胞聚集指数(IEA)及血细胞比容(Hct)较对照组明显升高,而红细胞变形指数(TK)则低于对照组。心肌损伤随超压增加而加重。结论密闭空间内冲击波致伤后能在短时间内对犬呼吸、心率、血压等生理指标及血液流变产生显著影响。Objective To investigate the pathophysiological effects after indoor blast injuries on the chest of dogs, and the hemorrheological changes after the injury. Methods According to the distance between the explosive resources and the weight of the explosive charge, the animals （ 24 dogs ） were randomly divided into 4 groups, among which were 3 injury groups and a control group. They were further divided into four groups on the basis of time points after the injury. Then the physiological, hemorrheological parameters and blood gas were monitored and the pathological changes of heart muscle was observed. Results After injury, the frequency of breath, heart rate, blood pressure and blood gas changed significantly in all three injuried groups as compared with the control group. The whole blood viscosity and the index of erythrocyte aggregation increased, as compared with the control group, but the index of erythrocyte deformability decreased. The result of pathological examination indicated that higher explosive pressure caused more severe heart muscle injuries. Conclusion Explosive injury could affect the hemorrheology statius and change physiological parameters in short period.

关 键 词：爆震伤 血液流变学 病理生理学 犬 

分 类 号：R642[医药卫生—外科学] R331[医药卫生—临床医学]