癫痫发作间期alpha波的窄带相位同步分析  

NARROW BAND PHASE SYNCHRONIZATION ANALYSIS OF EPILEPSY EEG IN ALPHA BAND

作　　者：裘嘉恒[1] 李雅堂[1] 许坤涵[1] 杨卓[2] 张涛[1] 

机构地区：[1]南开大学生命科学学院生物活性材料教育部重点实验室,天津300071 [2]南开大学医学院,天津300071

出　　处：《生物物理学报》2008年第3期221-226,共6页Acta Biophysica Sinica

基　　金：国家自然科学基金面上项目(30370386;30470453;30640037);天津市基础应用研究面上项目(06yfjwjc09400)~~

摘　　要：神经元同步化放电是癫痫发作的一个重要特征。作者提出并运用窄带相位同步技术对比分析了54个癫痫病人和10个正常成年人的脑电信号(EEG)数据。结果表明,相对于对照组,癫痫组的Alpha波的平均窄带相位同步值有显著下降(P=0.02058)。为了更准确地刻画和衡量癫痫组和其对照组在同步模式上的差异,提出了一个新的具体的量化指标,即alpha波的窄带相位同步发散率。分析结果显示,对照组的窄带相位同步发散率明显低于癫痫组(P=0.003060),说明对照组的alpha波振子间互诱导强度更高。这可能反映了癫痫组窄带相位同步发散率的升高及所代表的alpha振子间互诱导强度的减弱与患者在癫痫发作间期的状态有密切的联系。Neuron synchronization is an important characteristic of epilepsy. In this study, a novel technique of narrow band phase synchronization was applied to analyze EEG data of 54 epileptic patients and its control group with 10 subjects. A new statistic index, phase synchronization divergence of alpha frequency （PSDAF） measuring the difference of synchrony mode between epileptic and its control group, has been proposed. The data show that the average narrow band phase locking value of epilepsy group is significantly lower than that of control group （P=0.02058）. Furthermore, it was found that the PSDAF of control group was significantly lower compared to that of epilepsy group （P=0.003060）, which showed a stronger ＂mutual entrainment of an ensemble of non-linear alpha rhythm generators＂ in the neural system of subjects in the control group. The results suggest that there is close relationship between epileptic disease and such a phenomenon, which are the increase of PSDAF and the decrease of mutual entrainment of Alpha oscillations.

关 键 词：癫痫 相位同步 脑电波 alpha波段相位同步发散率 

分 类 号：R338[医药卫生—人体生理学]