蚌埠市0-5岁儿童出生缺陷危险因素的病例对照研究  

Caes-control study of risk factors on birth defect among children aged 0～5 years old in Bengbu

作　　者：芈静[1] 叶冬青[1] 孟灿[2] 陈雪芹[3] 周占伟[4] 程先进[4] 

机构地区：[1]安徽医科大学公共卫生学院,安徽合肥230032 [2]复旦大学公共卫生学院,上海200025 [3]蚌埠市计划生育服务站,安徽蚌埠233000 [4]蚌埠医学院预防医学系,安徽蚌埠233000

出　　处：《疾病控制杂志》2008年第3期218-220,共3页Chinese Journal of Disease Control and Prevention

基　　金：安徽省教育厅自然科学基金(KJ2007B334ZC);安徽省计生委(05-02)

摘　　要：目的探讨儿童出生缺陷发生的各种危险因素,为制定出生缺陷干预措施、做到优生优育提供依据。方法采用1∶1配对病例对照研究,对565对病例与对照进行调查,采用SPSS软件对所有调查因素进行单因素χ2检验和多因素的条件logistic回归分析。结果有统计学意义的危险因素是:家庭附近有污染(OR=5.18)、父母近亲结婚(OR=12.37)、有生育畸形儿史(OR=2.52)、孕育期接触有害物质(OR=10.81)、孕育期用药(OR=3.27)、孕育期接触宠物(OR=4.26)、父亲吸烟(OR=1.95)。结论家庭附近有污染、父母近亲结婚、有生育畸形儿史、孕育期接触有害物质、孕育期用药、孕育期接触宠物、父亲吸烟是出生缺陷的危险因素。Objective To investigate the risk factors of the Birth Defects （B. D） of 0- 5-year-old children in Bengbu so as to explore effective intervention strategy. Methods A 1 ： 1 matched case-control study was conducted to investigate 565 pairs of cases and the control. The data were analyzed for Single- and multiple-factor conditional logistic regression using SPSS software. Results The results of multiple regression model showed that the risk factors of BD were： domestic contamination （OR=5.18）, consanguineous marriage （OR=12.37）, bearing malformation child history （OR = 2.52）, exposure to harmful substance during pregnancy （ OR = 10.81 ）, drug usage during pregnancy （OR =3.27）, pet contacting during pregnancy （OR =4.26）, and father smoking （OR = 1.95）. Conclusions Birth defect risks include domestic contamination, consanguineous marriage, bearing malformation child history, exposure to harmful substance during pregnancy, drug usage during pregnancy, pet contacting during pregnancy, and father smoking.

关 键 词：畸形 危险因素 病例对照研究 

分 类 号：R321.6[医药卫生—人体解剖和组织胚胎学]