白细胞介素2与狂犬疫苗联合免疫小鼠的抗体动态观察  

Interleukin2 as an adjuvent to increase the antibodies level of inactivated rabies virus vaccine

作　　者：刘劲松[1] 伊纯德[1] 刘慧[1] 李燕[2] 陆虹[2] 宋绍勇[1] 崔景辉[1] 张守峰 

机构地区：[1]大连市解放军大连医高专 [2]北京市中国预防医学科学院病毒学研究所

出　　处：《解放军医学高等专科学校学报》1997年第4期4-6,共3页Clinical Journal of Medical Officer

摘　　要：组织培养制备的狂犬病毒灭活疫苗与重组白细胞介素２同时免疫ＢＡＬＢ／ｃ鼠和Ｓｗｉｓｓ鼠，检测不同时间的鼠血清中抗狂犬病毒ＩｇＧ抗体和中和抗体效价。结果显示，在白细胞介素２的作用下，抗体产生的时间提前，抗体效价提高（Ｐ＜０．０１），ＢＡＬＢ／ｃ鼠和Ｓｗｉｓｓ鼠比较，前者的抗体效价更高（Ｐ＜０．０１）。说明白细胞介素２可以提高小鼠的体液免疫反应。We were interested in determining whether the interleukin2 (IL2) could be an adjuvent to increase the immune response of mouse to inactivated rabies virus vaccine.BALB/c mice and Swiss mice were divided equally into two groups respectively.They were immunized by the inactivated rabies virus vaccine with IL2 or without IL2.The results showed that the antivirus IgGantibodies and virusneutralizing antibodies had appeared 5 days earlier for the group with IL2 than the one without IL2.The antibody titer had raised much higher for the group with IL2 than another one.

关 键 词：狂犬疫苗 白细胞介素2 中和抗体 

分 类 号：R512.990.1[医药卫生—内科学]