多囊卵巢综合征患者血清生长激素和泌乳素对左旋多巴反应的研究  

Responses of Growth Hormone and Prolactin to L Dopa in Women with Polycystic Ovarian Syndrome

作　　者：吴效科[1] 顾秋善[1] 苏延华[1] 

机构地区：[1]南京军区南京总医院妇产科

出　　处：《中华妇产科杂志》1997年第8期489-491,共3页Chinese Journal of Obstetrics and Gynecology

摘　　要：目的：探讨多囊卵巢综合征（ＰＣＯＳ）患者生长激素（ＧＨ）和泌乳素（ＰＲＬ）异常分泌的机理。方法：对黄体生成素（ＬＨ）／卵泡刺激素（ＦＳＨ）≥３的１５例患者（Ｉ型组）、ＬＨ／ＦＳＨ＜３的１５例患者（Ⅱ型组）以及２０例月经周期正常妇女（对照组），行左旋多巴（Ｌ－ＤＡ，５００ｍｇ）兴奋下丘脑－垂体轴功能试验，观察３组ＧＨ和ＰＲＬ的浓度变化。结果：在基础状态下，Ⅰ、Ⅱ型组的ＧＨ较低（Ｐ＜０．０１）、ＰＲＬ较高（Ｉ型组，Ｐ＜０．０５）；Ｌ－ＤＡ兴奋试验后，Ⅰ、Ⅱ型组ＧＨ的升高程度和ＰＲＬ的下降程度均低于对照组。结论：ＰＣＯＳ的ＧＨ和ＰＲＬ异常分泌可能与其中枢ＤＡ活性不足有关。Objective: To evaluate the altered dopaminergic modulation of growth hormone (GH) and prolactin (PRL) in polycystic ovarian syndrome (PCOS). Methods: Responses of GH and PRL to L Dopa (L DA) (500 mg) were observed in two PCOS groups (LH/FSH≥3, Group I, n =15; LH/FSH<3, Group Ⅱ, n =15) and the control ( n =20). Results: Significantly lower GH ( P <0.01) and higher PRL levels ( P <0.05 in group I) in the basal state, and lower responses of GH and PRL to L DA were found in two PCOS groups as compared with the control. Conclusion: The altered basal levels and blunted L DA evoked responses of GH and PRL suggest a relative decrease of the dopaminergic activity in PCOS patients.

关 键 词：多囊卵巢综合征 促生长素 催乳素 左旋多巴 

分 类 号：R711.75[医药卫生—妇产科学]