肺心病病人白细胞粘附功能与细胞粘附分子表达的变化  

THE CHANGES OF LEUKOCYTE ADHESION FUNCTION AND THE EXPRESSION OF CELL ADHESION MOLECULE IN PATIENTS WITH COR PULMONALE

作　　者：杨向荣[1,2,3,4] 陈作元 姜荣钦[1,2,3,4] 王雷 代有光[1,2,3,4] 王晓飞 

机构地区：[1]青岛市市立医院内科 [2]青岛医学院诊断学教研室 [3]青岛市中医院内科 [4]青岛市市立医院肿瘤科

出　　处：《青岛医学院学报》1997年第3期229-230,共2页Acta Academiae Medicinae Qingdao Universitatis

摘　　要：①目的探讨白细胞粘附功能（ＬＡＦ）和细胞粘附分子（ＣＡＭｓ）表达与肺心病的关系。②方法采用酶联免疫吸附法（ＥＬＩＳＡ），分别检测了６８例肺心病病人急性加重期和缓解期及４６例健康人外周血白细胞ＣＤ１８表达，血清可溶性细胞间粘附分子－１（ｓＩＣＡＭ－１）和白细胞粘附率（ＬＡＲ）的变化。③结果肺心病病人白细胞ＬＡＦ，ＣＤ１８表达及ｓＩＣＡＭ－１浓度明显增高，与对照组比较差异有极显著性（ｔ＝６．９０２，２１．４８２，３１．９２３，Ｐ均＜０．００１），且急性加重期较缓解期增高更明显（ｔ＝４．５７８，８．２６４，１７．８０６，Ｐ均＜０．００１）。肺心病病人白细胞ＬＡＦ与ＣＤ１８表达及ｓＩＣＡＭ－１浓度呈正相关（ｒ＝０．６７２，０．８０３，Ｐ均＜０．００１）。④结论ＬＡＦ增高和ＣＡＭｓ表达增加参与了肺心病的发生与发展，以及与病情严重程度均有密切关系。Objective To study the relationship between the leukocyte adhesion function(LAF), cell adhesion molecules(cAMS) expression and cor pulmonale. Methods The changes of leukocyte CD 18 expression, serum soluble intercellular molecule 1(sICAM 1) and leukocyte adhesion rate(LAR) were measured in 68 patients with cor pulmonale during the acute attack and remission stages and 46 controls by using ELISA, thrombus and platelet adhesion dual purpose apparatus. Results The LAR, expression of leukocyte CD 18 and sICAM 1 concentration were significantly higher in patients than those in controls( t= 6.902, 21.482, 31.923, P <0.001), and these indicators were more obvious in acute attack stage than those in remission stages( t=4.578, 8.264, 17.806, P<0.001 ). In cor pulmonale patients, the LAF was positively correlated with leukocyte CD 18 expression and sICAM 1 concentration( r=0.672, 0.803, P <0.001). Conclusion The increase of LAF and expression of cAMS may participate in the occurrence and development of cor pulmonale and these changes are closely related with the seriousness of patients.

关 键 词：肺心病 细胞粘附分子 白细胞 粘附性 

分 类 号：R541.5[医药卫生—心血管疾病]