适量运动对大鼠海马神经元脑源性神经营养因子表达的影响  

Influence of Aerobic Exercise on BDNF Expression in Rats Hippocampus

作　　者：刘晓莉[1] 李红[2] 乔德才[1] 

机构地区：[1]北京师范大学体育与运动学院,北京100875 [2]中北大学体育系,山西太原030051

出　　处：《沈阳体育学院学报》2008年第3期5-6,21,共3页Journal of Shenyang Sport University

基　　金：国家自然科学基金资助项目,项目编号:30470832;北京市自然科学基金资助项目,项目编号:5072024

摘　　要：通过观察适宜游泳运动后大鼠海马脑源性神经营养因子(BDNF)表达的变化,探讨运动促进脑健康的神经生物学机制。结果发现,CG大鼠海马有BDNF阳性细胞的蛋白表达,并以神经元表达为主。与CG相比,7SG和12SG大鼠海马CA1区BDNF阳性神经细胞数量均较CG显著或达极显著增加(P<0.05,P<0.01),且12SG较3SG显著增加(P<0.05)。从本实验结果证实,适量运动可增加BDNF的表达,促进脑神经功能的可塑性。This paper investigated the changes of brain-derived neurotrophic factor（BDNF） expression in rats hippocampus after swimming and discusses the neurobiology mechanism of aerobic exercise promoting the brain healthy. The results show that there is BDNF expression at hippocampus neuron. BDNF expression of 7SG and 12SG in hippocampus is significantly increased individually compared with CG （P 〈 0.05, P 〈 0.01 ）, 12SG in hippocampus is significantly increased compared with 3SG（P〈 0.05）. These results lead to conclusions that the aerobic swimming can increase the BDNF expression and promote the brain nerve plasticity.

关 键 词：有氧运动 大鼠 海马 脑源性神经生长因子 大脑神经的可塑性 

分 类 号：G804.7[文化科学—运动人体科学]